Ultrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis
Ultrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis
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DOI：
10.1007/bf01536630
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发表时间：
2005
影响因子：
3.1
通讯作者：
A. Maringhini;M. Cottone;E. Sciarrino;M. P. MarcenÒ;F. Seta;G. Fusco;Fortunato Rinaldi;L. Pagliaro
中科院分区：
文献类型：
--
作者：
A. Maringhini;M. Cottone;E. Sciarrino;M. P. MarcenÒ;F. Seta;G. Fusco;Fortunato Rinaldi;L. Pagliaro
评估了超声 (US) 和甲胎蛋白 (AFP) 在 363 名肝硬化 (C) 和临床怀疑 HCC 患者中诊断肝细胞癌 (HCC) 的准确性。分析 HCC 的超声图像及其与 AFP 值的关系。超声图像分布如下：47 名患者有超声致密病变； 30例患者出现低回声病灶； 47 名患者有混合型病变，其中 4 名患者出现局灶性肝内胆管扩张。 US的敏感性为90%；特异性为93.3%。 71 名患者 (48.6%) 血清 AFP 水平⩾500 ng/ml (RIA) 是诊断的第一线索；特异性为100%。在美国检测出 HCC 后的随访期间，28 名患者的 AFP 水平显着升高。未证明回声模式与血清 AFP 水平之间存在关系。提出了一种诊断 HCC 的算法。
The accuracy of ultrasound (US) and alpha-fetoprotein (AFP) in the diagnosis of hepatocellular carcinoma (HCC) in 363 patients with cirrhosis (C) and a clinical suspicion of HCC was assessed. The ultrasonographic patterns of HCC and their relationship with AFP values were analyzed. Echographic patterns were distributed as follows: 47 patients had sonodense lesions; 30 patients had hypoechoic lesions; 47 had mixed-pattern lesions, and in four patients focal dilated intrahepatic bile ducts were demonstrated. The sensitivity of US was 90%; specificity was 93.3%. Serum AFP level ⩾500 ng/ml (RIA) was the first clue to the diagnosis in 71 patients (48.6%); specificity was 100%. In 28 patients AFP levels became significantly elevated during follow-up after US detection of HCC. No relationship between echo pattern and serum AFP levels was demonstrated. An algorithm for diagnosis of HCC is proposed.