Apolipoprotein E epsilon 4 associated with chronic traumatic brain injury in boxing
Apolipoprotein E epsilon 4 associated with chronic traumatic brain injury in boxing
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DOI：
10.1001/jama.278.2.136
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发表时间：
1997-07-09
影响因子：
120.7
通讯作者：
Gandy, S
中科院分区：
文献类型：
--
作者：
Jordan, BD;Relkin, NR;Gandy, S
上下文。鉴于阿尔茨海默病和拳击痴呆之间的相似性，我们评估了载脂蛋白E （APOE）基因型与拳击手慢性创伤性脑损伤（CTBI）之间的关系，以确定是否存在对头部创伤影响的遗传易感性。目的：评估拳击手CTBI与APOE基因型的关系。设计和设置。-门诊24名志愿者和6名转诊拳击手的临床特征。-对30名年龄在23 - 76岁的职业拳击手进行了神经学和行为评估，并结合APOE基因分型。主要结果测量。-检测载脂蛋白E基因型与CTBI指标的关系。采用10分制临床评定量表（0-9分）——慢性脑损伤（CBI）量表来评定与拳击相关的创伤性脑病的严重程度，CTBI评分异常的拳击手根据其损伤是否可能与拳击有关进一步分类。分析得分与拳击暴露（场次）和APOE基因型的关系。- 30名拳击手中，正常11名（CBI评分为0），轻度缺陷12名（CBI评分为1-2），中度缺陷4名（CBI评分为3-4），重度缺陷3名（CBI评分为bb0 -4）。高暴露拳击手，即超过或等于12场职业比赛的拳击手，其CBI得分（平均[SD]， 2.6[1.9]）显著高于低暴露拳击手（平均[SD]， 0.3 [0.7]）
Context.-Given the similarities between Alzheimer disease and dementia pugilistica, we evaluated the relationship between apolipoprotein E (APOE) genotype and chronic traumatic brain injury (CTBI) in boxers to determine whether there is a genetic susceptibility to the effects of head trauma.Objective.-To assess the relationship between CTBI and APOE genotype in boxers.Design and Setting.-Clinical characterization of 24 volunteer and 6 referred boxers in an outpatient setting.Participants.-Thirty professional boxers aged 23 to 76 years underwent neurologic and behavioral assessment in conjunction with APOE genotyping.Main Outcome Measures.-Apolipoprotein E genotype was examined in relationship to measures of CTBI. A 10-point clinical rating scale (0-9), the Chronic Brain Injury (CBI) scale, was devised to assess the severity of traumatic encephalopathy associated with boxing, Boxers with abnormal CTBI scores were further classified on the basis of whether their impairments were possibly or probably related to boxing. Scores were analyzed in relation to boxing exposure (number of bouts) and APOE genotype.Results.-Among the 30 boxers, 11 were found to be normal (CBI score=0), 12 showed mild deficits (CBI score=1-2), 4 were moderately impaired (CBI score=3-4), and 3 showed signs of severe impairment (CBI score >4). High-exposure boxers tie, those with greater than or equal to 12 professional bouts) had significantly higher CBI scores (mean [SD], 2.6 [1.9]) than low-exposure boxers (mean [SD], 0.3 [0.7]) (P