Bio-ontologies: current trends and future directions
Bio-ontologies: current trends and future directions
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DOI：
10.1093/bib/bbl027
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发表时间：
2006-09-01
影响因子：
9.5
通讯作者：
Stevens, Robert
中科院分区：
文献类型：
--
作者：
Bodenreider, Olivier;Stevens, Robert
近年来，作为一门以知识为基础的学科，生物信息学在计算方面变得更加顺从。本体论最初是由计算机科学家倡导的一种克服异质性问题的技术，后来被生物学家自己用作一种一致地注释从基因到表型的特征的手段。在医学信息学中，被称为本体的人工制品已经被使用了更长的时间来产生用于编码方案的受控词典。在这篇文章中，我们回顾了目前本体论的地位，以及它们是如何在生物医学中制度化的。随着该领域的成熟，本体论的更古老的哲学方面也开始发挥作用。随之而来的是本体论的制度化和更大的形式化。我们回顾了这一趋势，以及它可能给本体论带来的好处，以及它们在生物医学中的使用。
In recent years, as a knowledge-based discipline, bioinformatics has been made more computationally amenable. After its beginnings as a technology advocated by computer scientists to overcome problems of heterogeneity, ontology has been taken up by biologists themselves as a means to consistently annotate features from genotype to phenotype. In medical informatics, artifacts called ontologies have been used for a longer period of time to produce controlled lexicons for coding schemes. In this article, we review the current position in ontologies and how they have become institutionalized within biomedicine. As the field has matured, the much older philosophical aspects of ontology have come into play. With this and the institutionalization of ontology has come greater formality. We review this trend and what benefits it might bring to ontologies and their use within biomedicine.