Differences in CT Perfusion Maps Generated by Different Commercial Software: Quantitative Analysis by Using Identical Source Data of Acute Stroke Patients
Differences in CT Perfusion Maps Generated by Different Commercial Software: Quantitative Analysis by Using Identical Source Data of Acute Stroke Patients
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DOI：
10.1148/radiol.254082000
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发表时间：
2010-01-01
期刊：
影响因子：
19.7
通讯作者：
Ogasawara, Kuniaki
中科院分区：
文献类型：
--
作者：
Kudo, Kohsuke;Sasaki, Makoto;Ogasawara, Kuniaki
目的：使用不同 CT 制造商提供的商用软件程序，检查从中风患者的相同源数据生成的计算机断层扫描 (CT) 灌注成像的定性和定量结果的变异性。材料和方法：获得机构审查委员会的批准和知情同意。使用五个商业软件包对10名脑卒中患者的CT灌注成像数据进行后处理，每个软件包都有不同的算法：奇异值分解（SVD）、最大斜率（MS）、逆滤波器（IF）、盒调制传递函数（bMTF），并使用定制的原始软件采用标准（sSVD）和块循环（bSVD）SVD方法。将显示脑血流量（CBF）、平均通过时间（MTT）和脑血容量（CBV）异常的区域相互比较并与最终梗塞区域进行比较。还检查了最终梗塞区域与未受影响侧的定量值的比率之间的差异。结果：CBF或MTT异常的区域以及这些值的比率在不同软件中存在显着差异，而CBV则稳定。使用 SVD 或 bMTF 分析的 CBF 或 MTT 异常区域与使用延迟敏感 sSVD 获得的区域相对应，但高估了最终梗死面积。使用 MS 或 IF 从软件获得的值与从延迟不敏感 bSVD 和最终梗塞面积获得的值非常一致。鉴于 CBF 和 MTT 之间的相似性，所有软件分为两组（即 sSVD 和 bSVD）。 CBF 或 MTT 的比率在两组内相关性良好，但在组间相关性较差。结论：即使使用相同的源数据，商业软件之间的 CT 灌注成像图也存在显着差异，这可能是由于示踪剂延迟敏感性的差异。 (C) 北美放射学会，2010
Purpose: To examine the variability in the qualitative and quantitative results of computed tomographic (CT) perfusion imaging generated from identical source data of stroke patients by using commercially available software programs provided by various CT manufacturers.Materials and Methods: Institutional review board approval and informed consent were obtained. CT perfusion imaging data of 10 stroke patients were postprocessed by using five commercial software packages, each of which had a different algorithm: singular-value decomposition (SVD), maximum slope (MS), inverse filter (IF), box modulation transfer function (bMTF), and by using custom-made original software with standard (sSVD) and block-circulant (bSVD) SVD methods. Areas showing abnormalities in cerebral blood flow (CBF), mean transit time (MTT), and cerebral blood volume (CBV) were compared with each other and with the final infarct areas. Differences among the ratios of quantitative values in the final infarct areas and those in the unaffected side were also examined.Results: The areas with CBF or MTT abnormalities and the ratios of these values significantly varied among software, while those of CBV were stable. The areas with CBF or MTT abnormalities analyzed by using SVD or bMTF corresponded to those obtained with delay-sensitive sSVD, but overestimated the final infarct area. The values obtained from software by using MS or IF corresponded well with those obtained from the delay-insensitive bSVD and the final infarct area. Given the similarities between CBF and MTT, all software were separated in two groups (ie, sSVD and bSVD). The ratios of CBF or MTTs correlated well within both groups, but not across them.Conclusion: CT perfusion imaging maps were significantly different among commercial software even when using identical source data, presumably because of differences in tracer-delay sensitivity. (C) RSNA, 2010