Predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care
Predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care
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DOI：
10.1097/qad.0b013e3283565df1
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发表时间：
2013-01-02
期刊：
影响因子：
3.8
通讯作者：
Sabin, Caroline A.
中科院分区：
文献类型：
--
作者：
Huntington, Susie E.;Thorne, Claire;Sabin, Caroline A.
Objectives: To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care.Methods: Data were obtained through the linkage of two separate studies: the UK Collaborative HIV Cohort study (UK CHIC), a cohort of adults attending 13 large HIV clinics; and the National Study of HIV in Pregnancy and Childhood (NSHPC), a national surveillance study of HIV-positive pregnant women. Pregnancy incidence was measured using the proportion of women in UK CHIC with a pregnancy reported to NSHPC. Generalized estimating equations were used to identify predictors of pregnancy and assess changes in pregnancy incidence in 2000-2009.Results: The number of women accessing care at UK CHIC sites increased as did the number of pregnancies. Older women were less likely to have a pregnancy [adjusted relative rate (aRR) 0.44 per 10 year increment in age, [95% confidence interval (Cl) (0.41-0.46)], P < 0.001] as were women with CD4 cell count less than 200 cells/mu l compared with CD4 cell count 200-350 cells/mu l [aRR 0.65 (0.55-0.77), P< 0.001] and women of white ethnicity compared with women of black African ethnicity [aRR 0.67 (0.57-0.80), P < 0.001]. The likelihood that women had a pregnancy increased over the study period [aRR 1.05 (1.03-1.07), P
