Effect of the PPARγ C161T Gene Variant on Serum Lipids in Ischemic Stroke Patients with and Without Type 2 Diabetes Mellitus
Effect of the PPARγ C161T Gene Variant on Serum Lipids in Ischemic Stroke Patients with and Without Type 2 Diabetes Mellitus
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DOI：
10.1007/s12031-014-0326-3
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发表时间：
2014-12-01
影响因子：
3.1
通讯作者：
Slimane, Mohamed Naceur
中科院分区：
文献类型：
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作者：
Chehaibi, Khouloud;Nouira, Samir;Slimane, Mohamed Naceur
过氧化物酶体增殖物激活受体γ（过氧化物酶体增殖物激活受体γ）是一种配体激活的转录因子，参与脂质代谢、糖尿病、肥胖、动脉粥样硬化形成和炎症的调节。PPAR γ基因变异与代谢和心血管疾病有关。本研究旨在探讨2型糖尿病（T2 DM）患者中过氧化物酶体增殖物激活受体γ C161 T多态性与缺血性脑卒中（IS）风险的关系。共招募了196例IS患者（117例糖尿病患者和79例非糖尿病患者）和192例对照者参加本研究。采用PCR-RFLP技术进行PPAR γ C161 T基因分型。对照组161 T等位基因高于IS组（伴或不伴T2 DM）。调整多个危险因素后，T等位基因携带者IS风险显著降低（OR = 0.575，95% CI 0.348-0.951，p = 0.030），而CC纯合子IS风险显著增加（OR = 1.85，95% CI 1.23-2.62）。CC纯合子携带者的TG和ApoB水平显著高于T等位基因携带者。这些结果表明，C161 T可能通过调节脂肪代谢，特别是TG和ApoB，降低IS合并T2 DM患者的风险。
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated transcription factor involved in the regulation of lipid metabolism, diabetes, obesity, atherogenesis and inflammation. PPAR gamma genetic variation has been associated with metabolic and cardiovascular diseases. The aim of this study was to explore, for the first time, the relationship between PPAR gamma C161T polymorphism and the risk of ischemic stroke (IS) among patients with type 2 diabetes mellitus (T2DM). A total of 196 patients with IS (117 diabetics and 79 nondiabetics) and 192 controls were recruited to enroll in this study. PPAR gamma C161T genotyping was performed by PCR-RFLP technique. The 161T allele as compared with C allele was found to be higher in controls than in IS patients (with or without T2DM). After adjusting for multiple risk factors, the T allele carriers had significantly reduced IS risk (OR = 0.575, 95 % CI 0.348-0.951, p = 0.030) compared to the CC homozygotes which increased significantly the risk in IS patients with T2DM (OR = 1.85, 95 % CI 1.23-2.62). Moreover, the triglycerides (TG) and ApoB levels in CC homozygote carriers were significantly higher than those in T allele carriers. These results indicate that the C161T of PPAR gamma may reduce the risk of IS by modulation of adipose metabolism especially TG and ApoB in IS patients with T2DM.