Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population
Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population
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DOI：
10.1016/j.schres.2005.12.854
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发表时间：
2006-04
影响因子：
4.5
通讯作者：
N. Takahashi;R. Ishihara;S. Saito;Nobuhisa Maemo;Nagisa Aoyama;X. Ji;H. Miura;M. Ikeda;N. Iwata;Tatsuyo Suzuki;T. Kitajima;Y. Yamanouchi;Y. Kinoshita;N. Ozaki;T. Inada
中科院分区：
文献类型：
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作者：
N. Takahashi;R. Ishihara;S. Saito;Nobuhisa Maemo;Nagisa Aoyama;X. Ji;H. Miura;M. Ikeda;N. Iwata;Tatsuyo Suzuki;T. Kitajima;Y. Yamanouchi;Y. Kinoshita;N. Ozaki;T. Inada
据报道，嗜铬粒蛋白A（CHGA）基因的表达减少，在前额叶皮层和脑脊液的精神分裂症患者。对633名精神分裂症患者和589名健康对照者进行了CHGA基因内SNPs的单标记和单倍型分析。一个SNP标记rs9658635（p=0.0269）和一个2标记单倍型（p=0.0016）与精神分裂症显著相关。rs9658635的显著相关性随后在第二个独立队列（377例精神分裂症和338例对照样本）中重复（p=0.007）。这些结果表明，CHGA基因与日本人群患精神分裂症的风险有关。
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.