Cholesterylation: a tail of hedgehog
Cholesterylation: a tail of hedgehog
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DOI：
10.1042/bst20150032
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发表时间：
2015-04-01
影响因子：
3.9
通讯作者：
Tate, Edward W.
中科院分区：
文献类型：
--
作者：
Ciepla, Paulina;Magee, Anthony I.;Tate, Edward W.
胆固醇化是甾醇与蛋白质的翻译后附着。这种修饰是刺猬蛋白（Hh）单一家族的特征。 Hh 是一种成熟的形态发生分子，对胚胎发育非常重要。还发现它参与了许多癌症类型的进展。在此，我们描述了胆固醇化 Hh 的生物合成机制、这种不寻常的修饰对蛋白质功能的作用以及可用于在体外和体内特异性靶向这种修饰的新型化学探针。
Cholesterylation is a post-translational attachment of sterol to proteins. This modification has been a characteristic of a single family of hedgehog proteins (Hh). Hh is a well-established morphogenic molecule important in embryonic development. It was also found to be involved in the progression of many cancer types. Herein, we describe the mechanism of biosynthesis of cholesterylated Hh, the role of this unusual modification on protein functions and novel chemical probes, which could be used to specifically target this modification, both in vitro and in vivo.