High plasma level of remnant-like particle cholesterol in the metabolic syndrome
High plasma level of remnant-like particle cholesterol in the metabolic syndrome
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DOI：
10.2337/diacare.28.10.2514
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发表时间：
2005-10-01
期刊：
影响因子：
16.2
通讯作者：
Imaizumi, T
中科院分区：
文献类型：
--
作者：
Satoh, A;Adachi, H;Imaizumi, T
目的——代谢综合征与心血管疾病的高发病率相关，即使该综合征中存在的异常很轻微。代谢综合征的潜在机制尚未阐明。我们调查了一种强致动脉粥样硬化脂蛋白，即残留样颗粒（RLP）脂蛋白胆固醇，在代谢综合征中是否升高。 研究设计和方法——我们对日本一个农村社区的居民进行了健康检查。完整的数据集，包括空腹 RLP 胆固醇水平，来自 1,261 名没有糖尿病且未服用降脂药物的受试者（509 名男性和 752 名女性）。通过问卷调查确定受试者的病史、饮酒情况和吸烟习惯。 结果 - 通过单变量分析，代谢综合征的所有组成部分均与 RLP 胆固醇显着相关。总胆固醇和吸烟习惯也与 RLP 胆固醇呈正相关。患有代谢综合征的受试者仅表现出各组成部分的轻微异常。当 RLP 胆固醇水平按代谢综合征的成分数量进行分层时，RLP 胆固醇水平与成分数量之间存在很强的相关性（P < 0.001 和 F = 72.7）。结论 - RLP 胆固醇水平在代谢综合征中升高，这种升高可能是代谢综合征中心血管疾病高发病率的基础。
OBJECTIVE - The metabolic syndrome is associated with a high incidence of cardiovascular disease even when the abnormalities present in the syndrome are mild. The underlying mechanism of the metabolic syndrome has not been elucidated. We investigated whether a strong atherogenic lipoprotein, remnant-like particle (RLP) lipoprotein cholesterol, is elevated in the metabolic syndrome.RESEARCH DESIGN AND METHODS - We performed a health examination among the residents of a rural community in Japan. Complete datasets, including fasting RLP cholesterol levels, were obtained in 1,261 subjects (509 men and 752 women) without diabetes an who were not taking lipid-lowering drugs. The subjects' medical history, use of alcohol, and smoking habits were ascertained by a questionnaire.RESULTS - All of the components of the metabolic syndrome were significantly related to RLP cholesterol by univariate analysis. Total cholesterol and smoking habits were also positively associated with RLP cholesterol. The subjects with the metabolic syndrome showed only mild abnormalities of each component. When RLP cholesterol levels were stratified by the number of the components of the metabolic syndrome, there was a strong association between RLP cholesterol levels and the number of components (P < 0.001 and F = 72.7).CONCLUSIONS - RLP cholesterol levels are elevated in the metabolic syndrome, and this elevation may underlie the high incidence of cardiovascular disease in the metabolic syndrome.