The protective effect of SARS-CoV-2 antibodies in Scottish healthcare workers
The protective effect of SARS-CoV-2 antibodies in Scottish healthcare workers
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DOI：
10.1183/23120541.00080-2021
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发表时间：
2021-04-01
影响因子：
4.6
通讯作者：
Chalmers, James D.
中科院分区：
文献类型：
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作者：
Abo-Leyah, Hani;Gallant, Stephanie;Chalmers, James D.
背景：卫生保健工作者（HCWs）被认为是严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）感染的高危人群。目前尚不清楚自然产生的SARS-CoV-2抗体在多大程度上可以防止再次感染。方法：对2020年5月至9月在苏格兰（英国）的HCWs进行前瞻性观察研究。采用Siemens SARS-CoV-2总抗体测定法确定该队列的血清阳性率。研究人员对年龄和性别与当地一般人口相匹配的对照组进行了比较。记录抗体检测后的新感染（截至2020年12月2日），以确定SARS-CoV-2抗体的存在是否可以防止再次感染。结果：本研究共招募了2063名卫生和社会护理工作者。入组时，300名医护人员抗体检测呈阳性（14.5%）。231份对照血清中有11份检测呈阳性（4.8%）。因此，HCWs检测阳性的可能性增加(OR 3.4, 95% CI 1.85-6.16; p
Background: Healthcare workers (HCWs) are believed to be at increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It is not known to what extent the natural production of antibodies to SARS-CoV-2 is protective against re-infection.Methods: A prospective observational study of HCWs in Scotland (UK) from May to September 2020 was performed. The Siemens SARS-CoV-2 total antibody assay was used to establish seroprevalence in this cohort. Controls, matched for age and sex to the general local population, were studied for comparison. New infections (up to 2 December 2020) post antibody testing were recorded to determine whether the presence of SARS-CoV-2 antibodies protects against re-infection.Results: A total of 2063 health and social care workers were recruited for this study. At enrolment, 300 HCWs had a positive antibody test (14.5%). 11 out of 231 control sera tested positive (4.8%). HCWs therefore had an increased likelihood of a positive test (OR 3.4, 95% CI 1.85-6.16; p