Breast cancer with synchronous metastases: Trends in survival during a 14-year period
Breast cancer with synchronous metastases: Trends in survival during a 14-year period
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DOI：
10.1200/jco.2004.08.095
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发表时间：
2004-08-15
影响因子：
45.3
通讯作者：
Spielmann, M
中科院分区：
文献类型：
--
作者：
Andre, F;Slimane, K;Spielmann, M
虽然在20世纪90年代，新药被批准用于治疗转移性乳腺癌，但尚不清楚它们的使用是否改变了患者的日常实践结果。本研究旨在确定生存是否随着时间的推移，乳腺癌患者谁转移在diagnosis.Patients和MethodsA共724例已在三个法国癌症中心治疗的最初转移性乳腺癌1987年和2000年之间，343被诊断为1987年和1993年之间，和381被诊断为1994年和2000年之间。这些患者的肿瘤特征，治疗和结果进行了比较，卡方（2）检验，对数秩检验，和考克斯回归analysis.ResultsCharacteristics之间没有显着差异的患者诊断为1987年至1993年和诊断为1994年至2000年。1987年至1994年治疗的10%的患者和1994年至2000年治疗的58%的患者接受了紫杉烷或新的芳香酶抑制剂。1987年至1993年接受治疗的患者的3年总生存率为27%，1994年至2000年接受治疗的患者的3年总生存率为44%（P < .001）。治疗期（1994年至2000年v 1987年至1993年）是一个预后因素在多变量分析（相对危险度，0.6; P <0.001）。结论乳腺癌患者的生存与转移诊断随着时间的推移有所改善。这项研究强烈表明，这种改善与治疗有关。(C)2004年，美国临床肿瘤学会。
PurposeAlthough new drugs were approved during the 1990s for the treatment of metastatic breast cancer, it is not clear whether their use has changed the outcome of patients in daily practice. This study sought to determine whether survival has improved over time for breast cancer patients who had metastases at diagnosis.Patients and MethodsA total of 724 patients have been treated in three French cancer centers for an initially metastatic breast cancer between 1987 and 2000; 343 were diagnosed between 1987 and 1993, and 381 were diagnosed between 1994 and 2000. Tumor characteristics, treatments, and outcomes of these patients were compared by chi(2) test, log-rank test, and Cox regression analysis.ResultsCharacteristics were not different between the patients diagnosed from 1987 to 1993 and those diagnosed from 1994 to 2000. Ten percent of patients treated from 1987 to 1994 and 58% of patients treated from 1994 to 2000 have received either a taxane or a new aromatase inhibitor. The 3-year overall survival rates were 27% for patients treated from 1987 to 1993 and 44% for patients treated from 1994 to 2000 (P < .001). The treatment period (1994 to 2000 v 1987 to 1993) was a prognostic factor in multivariate analysis (relative risk, 0.6; P < .001).ConclusionThe survival of breast cancer patients presenting with metastases at diagnosis has improved over time. This study strongly suggests that this improvement is related to treatment. (C) 2004 by American Society of Clinical Oncology.