Photo-Oxygenation: An Innovative New Therapeutic Approach Against Amyloidoses
Photo-Oxygenation: An Innovative New Therapeutic Approach Against Amyloidoses
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光氧合：一种针对淀粉样变性的创新治疗方法
DOI：
10.1007/978-3-030-78787-5_52
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Tomita Taisuke
中科院分区：
文献类型：
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作者：
Ikeda Tetsuo;Hori Yukiko;Sohma Youhei;Kanai Motomu;Tomita Taisuke
许多类型的淀粉样变性的病理特征在于淀粉样蛋白沉积，其由异常聚集的蛋白质形成的原纤维组成，在各种外周组织和中枢神经系统（CNS）中。神经退行性疾病，如阿尔茨海默病（AD）、帕金森病（PD）、额颞叶痴呆（FTD）和肌萎缩侧索硬化（ALS），是众所周知的CNS淀粉样变性，其特征在于细胞内外的淀粉样蛋白沉积。每种疾病的淀粉样蛋白具有不同的一级序列，它们通常作为可溶性蛋白发挥功能。然而，这些蛋白质都聚集并形成具有共同分子间三级结构的淀粉样蛋白，即交叉β折叠结构，最终导致每种疾病的发作。因此，抑制淀粉样蛋白的聚集或有效清除已经形成的淀粉样蛋白被认为是有希望的抗淀粉样变性的治疗策略
Many types of amyloidoses are pathologically characterized by the deposition of amyloid, which is comprised of fibrils formed by abnormally aggregated proteins, in various peripheral tissues and the central nervous system (CNS). Neurodegenerative disorders, such as Alzheimer disease (AD), Parkinson disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), are well-known CNS amyloidoses that are characterized by amyloid deposition both inside and outside of cells. The amyloidogenic proteins of each disease have distinct primary sequences, and they normally function as soluble proteins. However, these proteins all aggregate and form amyloid with a common intermolecular tertiary structure, namely, a cross-β-sheet structure, finally leading to the onset of each disease. Therefore, inhibition of the aggregation of amyloid proteins or efficient clearance of the already formed amyloids are thought to be promising therapeutic strategies against amyloidoses