CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in Gastric Smooth Muscle of Diabetic Rats.
CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in Gastric Smooth Muscle of Diabetic Rats.
复制标题
糖尿病大鼠胃平滑肌中 CNP-pGC-cGMP-PDE3-cAMP 信号通路上调
DOI：
10.1155/2015/305258
复制
发表时间：
2015
影响因子：
2
通讯作者：
Xu WX
中科院分区：
文献类型：
--
作者：
Cai YL;Zhang MH;Huang X;Jiang JZ;Piao LH;Jin Z;Xu WX
Our previous studies have shown that CNP-NPR-B/pGC-cGMP is upregulated in the diabetic rats. The present study was designed to determine whether the upregulation of CNP-NPR-B/pGC-cGMP signal pathway affects cGMP-PDE3-cAMP signal pathway in diabetic gastric smooth muscle. The gastric smooth muscle motility was observed by using isometric measurement. PDEs expressions in diabetic gastric smooth muscle tissue were observed by using immunohistochemistry, Western blotting, and RT-PCR methods. The results demonstrated that the inhibitory effect of CNP on the spontaneous contraction of gastric antral circular smooth muscle was potentiated in STZ-induced diabetic rat. CNP-induced increase of cGMP and cAMP was much higher in diabetic gastric smooth muscle tissue than in controls. The expression of PDE3 is downregulated while the levels of gene expression of PDE1, PDE2, PDE4, and PDE5 were not altered in the diabetic gastric smooth muscle tissue. The results suggest that the sensitivity of gastric smooth muscle to CNP is potentiated via activation of CNP-pGC-cGMP-PDE3-cAMP signal pathway in STZ-induced diabetic rats, which may be associated with diabetes-induced gastric motility disorder.
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影响因子：
7.3
作者：
SMALL, RC;BOYLE, JP;WATT, AJ
通讯作者：
WATT, AJ
影响因子：
20.1
作者：
Wen, JF;Cui, X;Cho, KW
通讯作者：
Cho, KW
利钠肽依赖性 cGMP 信号通路增强链脲佐菌素诱导的糖尿病大鼠胃平滑肌的松弛
影响因子：
3.1
作者：
Xu, Dong-Yuan;Liu, Lan;Xu, Wen-Xie
通讯作者：
Xu, Wen-Xie
C型利钠肽对不同动物胃动力影响的比较研究。
影响因子：
4.3
作者：
Guo, HS;Jin, Z;Xu, WX
通讯作者：
Xu, WX
STZ 诱导的糖尿病小鼠中糖尿病诱导的胃 ICC 丧失伴随利尿钠肽信号通路上调
影响因子：
3
作者：
Wu, Yi-Song;Lu, Hong-Li;Xu, Wen-Xie
通讯作者：
Xu, Wen-Xie