Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol.
Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol.
复制标题
低剂量硫利达嗪和低剂量氟哌啶醇的心脏安全性比较。
DOI：
10.1111/j.1365-2125.2004.02098.x
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
Strom,BrianL
中科院分区：
文献类型：
--
作者：
Hennessy,Sean;Bilker,WarrenB;Knauss,JillS;Kimmel,StephenE;Margolis,DavidJ;Morrison,MaryF;Reynolds,RobertF;Glasser,DaleB;Strom,BrianL
目的比较硫硝嗪和氟哌啶醇服用者室性心律失常、猝死和不明原因或无人看管死亡的发生率。方法对1987年至2000年6月29日在英国全科医学研究数据库（GPRD）中使用噻嗪和氟哌啶醇的患者进行观察性队列研究。每个研究处方对患者进行了30天的随访。所关注的事件是室性心律失常、猝死或不明原因或无人照料的死亡的诊断。采用Cox回归计算率比（rr）和95%置信区间（ci），检查潜在的混杂因素，并检查剂量-反应关系。结果在GPRD中，硫硝嗪和氟哌啶醇主要用于老年患者，且剂量低（硫硝嗪中位日剂量31 mg，氟哌啶醇中位日剂量1.8 mg）。硫硝嗪的使用与室性心律失常、猝死、不明原因或无人照料的死亡发生率之间没有关联（校正RR 0.9, 95% CI 0.7, 1.1）。在观察到的范围内，这一比率似乎没有随着剂量的增加而增加。结论低剂量噻嗪与氟哌啶醇具有相似的心脏安全性。
AimTo compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol.MethodsObservational cohort study of thioridazine and haloperidol users in the UK General Practice Research Database (GPRD) using data from 1987 through 29 June 2000. Patients were followed for 30 days following each study prescription. The event of interest was a diagnosis of ventricular arrhythmia, sudden death, or unexplained or unattended death. Cox regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs), to examine potential confounding factors, and to examine dose–response relationships.ResultsUse of thioridazine and haloperidol in the GPRD was primarily in older patients, at low dose (median daily dose 31 mg thioridazine, 1.8 mg haloperidol). There was no association between thioridazine use and the rate of ventricular arrhythmia, sudden death, and unexplained or unattended death (adjusted RR 0.9, 95% CI 0.7, 1.1). The rate did not appear to increase with dose for either drug over the range observed.ConclusionsThese results suggest that low‐dose thioridazine and haloperidol have similar cardiac safety.