Lymphedema and obesity: is there a link?
Lymphedema and obesity: is there a link?
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淋巴水肿和肥胖症：是否有联系？
DOI：
10.1097/prs.0000000000000268
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发表时间：
2014-07
影响因子：
3.6
通讯作者：
Greene AK
中科院分区：
文献类型：
--
作者：
Mehrara BJ;Greene AK
淋巴水肿是一种慢性疾病，在发达国家，最常见的发生在癌症治疗的淋巴清扫后。虽然淋巴水肿的病理生理机制尚不清楚，但该病的组织学特征是纤维化和异常脂肪沉积。临床研究表明，肥胖和术后体重增加是淋巴水肿发生的重要危险因素。事实上，最近的研究表明，极度肥胖会导致淋巴功能明显受损和原发淋巴水肿。这篇专题文章的目的是回顾肥胖症和淋巴水肿相关的证据。此外，作者还回顾了最近的研究，这些研究分析了可能导致这种关系的细胞机制，目的是强调可能具有重大翻译潜力的研究领域。
Lymphedema is a chronic disorder that, in developed countries, occurs most commonly after lymph node dissection for cancer treatment. Although the pathophysiology of lymphedema is unknown, the disease is characterized histologically by fibrosis and abnormal adipose deposition. Clinical studies have provided evidence that obesity and postoperative weight gain are significant risk factors for the development of lymphedema. In fact, recent studies have shown that extreme obesity can result in markedly impaired lymphatic function and primary lymphedema. The aim of this Special Topic article is to review evidence linking obesity and lymphedema. In addition, the authors review recent studies that have analyzed the cellular mechanisms that may be responsible for this relationship, with a goal of highlighting areas of research that may have significant translational potential.