Simian immunodeficiency virus (SIV) from sun-tailed monkeys (Cercopithecus solatus):: Evidence for host-dependent evolution of SIV within the C. lhoesti superspecies
Simian immunodeficiency virus (SIV) from sun-tailed monkeys (Cercopithecus solatus):: Evidence for host-dependent evolution of SIV within the C. lhoesti superspecies
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DOI：
10.1128/jvi.73.9.7734-7744.1999
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发表时间：
1999-09-01
影响因子：
5.4
通讯作者：
Hirsch, VM
中科院分区：
文献类型：
--
作者：
Beer, BE;Bailes, E;Hirsch, VM
最近，我们报道了来自中非 l'hoest 猴 (Cercopithecus lhoesti lhoesti) 的猿猴免疫缺陷病毒 (SIVlhoest) 的特征，揭示了与从山魈中分离出的 SIV (SIVmnd) 的远缘关系。本报告描述了从健康的野生太阳尾猴（Cercopithecus lhoesti solatus）（l'hoest 超种的另一个成员）中分离出的新型 SIV（SIVsun）。 SNsun 在多种人类 T 细胞系以及猕猴 (Macaca spp.) 和帕塔猴 (Erythrocebus patas) 的外周血单核细胞中复制。获得了SIVsun的全长感染性克隆，遗传分析表明SIVsun与SIVlhoest关系最密切，其氨基酸同一性在Gag中为71％，在Pol中为73％，在Env中为67％。这种程度的相似性让人想起从非洲绿猴、黑长尾猴和坦塔鲁斯物种中观察到的 SIVagm 分离株。尽管 SNsun 和 SIVlhoest 的栖息地不同，但它们之间的密切关系与共同祖先的进化一致，这为灵长类慢病毒家族的古老性质提供了进一步的证据。此外，这一观察结果使我们建议 SIVmnd 谱系应指定为 SIVlhoest 谱系。
Recently we reported the characterization of simian immunodeficiency virus (SIVlhoest) from a central African l'hoest monkey (Cercopithecus lhoesti lhoesti) that revealed a distant relationship to SIV isolated from a mandrill (SIVmnd). The present report describes a novel SIV (SIVsun) isolated from a healthy, wild-caught sun-tailed monkey (Cercopithecus lhoesti solatus), another member of the l'hoest superspecies. SNsun replicated in a variety of human T-cell lines and in peripheral blood mononuclear cells of macaques (Macaca spp.) and patas monkeys (Erythrocebus patas). A full-length infectious clone of SIVsun was derived, and genetic analysis revealed that SIVsun was most closely related to SIVlhoest, with an amino acid identity of 71% in Gag, 73% in Pol, and 67% in Env. This degree of similarity is reminiscent of that observed between SIVagm isolates from vervet, grivet, and tantalus species of African green monkeys. The close relationship between SNsun and SIVlhoest, despite their geographically distinct habitats, is consistent with evolution from a common ancestor, providing further evidence for the ancient nature of the primate lentivirus family. In addition, this observation leads us to suggest that the SIVmnd lineage should be designated the SIVlhoest lineage.