Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies.
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies.
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DOI：
10.1186/s12890-017-0397-3
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发表时间：
2017-03-20
影响因子：
3.1
通讯作者：
ALEC study
中科院分区：
文献类型：
--
作者：
Machin M;Amaral AF;Wielscher M;Rezwan FI;Imboden M;Jarvelin MR;Adcock IM;Probst-Hensch N;Holloway JW;Jarvis DL;ALEC study
外周血中的表观遗传变异有潜力作为疾病的生物标志物。本系统综述评估了基于人群的研究中肺功能和慢性阻塞性肺疾病 (COPD) 与外周血 DNA 甲基化谱的关联。检索了在线数据库 Medline、Embase 和 Web of Science。搜索谷歌学术来识别灰色文献。去除重复文章后，1155篇文章由两名研究者独立筛选。选择同行评审的基于人群的研究报告进行全文审查，这些研究检查了已测量肺功能（FEV1、FEV1/FVC 比率）或已知 COPD 状态的参与者的外周血 DNA 甲基化。六篇文章适合纳入。提取了有关研究特征、设计、方法和结论的信息。根据已发表的结果进行叙述综合。六篇文章中的三篇评估了 COPD 与 DNA 甲基化的关联，其中两篇还包括与肺功能的关联。总体而言，五份报告研究了肺功能与 DNA 甲基化谱的关联。六篇文章中有五篇报告了“显着”结果。然而，在针对 COPD 状态或肺功能值的研究中，没有发现一致的 CpG 位点。肺功能下降或慢性阻塞性肺病患者外周血中的 DNA 甲基化模式可能与肺功能正常的患者不同。然而，这项系统评价并未发现肺功能或 COPD 与差异甲基化 CpG 位点之间存在任何一致的关联。采用纵向设计来解决反向因果关系的大型研究可能会被证明是一个更富有成效的研究领域。普洛斯彼罗 2016：CRD42016037352。本文的在线版本 (doi:10.1186/s12890-017-0397-3) 包含补充材料，可供授权用户使用。
Epigenetic variations in peripheral blood have potential as biomarkers for disease. This systematic review assesses the association of lung function and chronic obstructive pulmonary disease (COPD) with DNA methylation profiles in peripheral blood from population-based studies. Online databases Medline, Embase, and Web of Science were searched. Google Scholar was searched to identify grey literature. After removing duplicate articles, 1155 articles were independently screened by two investigators. Peer reviewed reports on population-based studies that examined peripheral blood DNA methylation in participants with measured lung function (FEV1, FEV1/FVC ratio) or known COPD status were selected for full-text review. Six articles were suitable for inclusion. Information regarding study characteristics, designs, methodologies and conclusions was extracted. A narrative synthesis was performed based on published results. Three of the six articles assessed the association of COPD with DNA methylation, and two of these also included associations with lung function. Overall, five reports examined the association of lung function with DNA methylation profiles. Five of the six articles reported ‘significant’ results. However, no consistent CpG sites were identified across studies for COPD status or lung function values. DNA methylation patterns in peripheral blood from individuals with reduced lung function or COPD may be different to those in people with normal lung function. However, this systematic review did not find any consistent associations of lung function or COPD with differentially methylated CpG sites. Large studies with a longitudinal design to address reverse causality may prove a more fruitful area of research. PROSPERO 2016: CRD42016037352. The online version of this article (doi:10.1186/s12890-017-0397-3) contains supplementary material, which is available to authorized users.