Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses.
Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses.
复制标题
单次和多次口服剂量后大鼠体内溴二氯甲烷的代谢和分布。
DOI：
10.1080/15287399009531406
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Jeffcoat,AR
中科院分区：
文献类型：
--
作者：
Mathews,JM;Troxler,PS;Jeffcoat,AR
The disposition of [14C]bromodichloromethane (BDCM) was studied in male Fischer rats after single oral doses of 1, 10, 32, or 100 mg/kg and 10‐d repeat oral dosing of 10 or 100 mg/kg/d. Methods were developed to quantitate exhaled14CO and14CO2. Bromodichloromethane was extensively (∼80–90%) metabolized within 24 h postdosing with ∼70–80% of the administered dose appearing as14CO2and ∼3–5% as14CO. Urinary and fecal elimination were low, accounting for 4–5% and 1–3% of the dose, respectively. Oral administration of BDCM at a level of 10 mg/kg/d for 10 d did not result in the bioaccumulation or altered disposition of the test chemical, but during the course of the repeat 100 mg/kg/d dosing the rate of production of14CO2increased, suggesting that this dose of BDCM induced its own metabolism. Persistence of radiolabeled residues in tissues collected 24 h after single‐dose administration was low (3–4% of dose), with the most marked accumulation (1–3% of dose) in liver. Kidney tissue, particularly the cortical region, also contained significant concentrations of residues.
