Evaluation of aneurysm-associated wall shear stress related to morphological variations of circle of Willis using a microfluidic device
Evaluation of aneurysm-associated wall shear stress related to morphological variations of circle of Willis using a microfluidic device
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DOI：
10.1016/j.jbiomech.2014.11.018
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发表时间：
2015-01-21
影响因子：
2.4
通讯作者：
Park, Hun-Kuk
中科院分区：
文献类型：
--
作者：
Nam, Seong-Won;Choi, Samjin;Park, Hun-Kuk
尽管微流控系统一直是分析化学、生命科学和医学研究的重要工具，但其在药物筛选和生物传感器方面的应用相当有限。在这里，我们描述了一种由代表血流动力学脑血管系统的多层微通道系统组成的微流体装置。我们使用该系统分析了与 Willis 环 (CoW) 中动脉瘤形成相关的壁剪应力及其形态变化。该装置由气动阀控制，气动阀通过关闭相关通道来闭塞各种主要动脉。血流动力学分析表明，前交通动脉（ACoA）发生较高程度的剪切应力，特别是后交通动脉（PCoA）和P1段的发育不全区域。此外，颈总动脉（CCA）或大脑中动脉（MCA）的闭塞增加了剪切应力，而椎动脉（VA）的闭塞降低了剪切应力。这些结果表明，CoW 的形态变化可能会影响壁剪切应力增加导致的动脉瘤形成。因此，本文描述的技术提供了一种新的方法来研究以前的临床研究无法获得的复杂脑血管系统的血流动力学。 (C) 2014 Elsevier Ltd. 保留所有权利。
Although microfluidic systems have been important tools in analytical chemistry, life sciences, and medical research, their application was rather limited for drug-screening and biosensors. Here, we described a microfluidic device consisting of a multilayer micro-channel system that represented the hemodynamic cerebral vascular system. We analyzed wall shear stresses related to aneurysm formation in the circle of Willis (CoW) and their morphological variations using this system. This device was controlled by pneumatic valves, which occluded various major arteries by closing the associated channels. The hemodynamic analysis indicated that higher degrees of shear stress occurred in an anterior communicating artery (ACoA), particularly in the hypoplastic region of the posterior communicating artery (PCoA) and the P1 segment. Furthermore, occlusion of a common carotid artery (CCA) or a middle cerebral artery (MCA) increased the shear stress, whereas occlusion of a vertebral artery (VA) decreased the shear stress. These results indicate that the morphological variation of the CoW may affect aneurysm formation resulting from increased wall shear stress. Therefore, the technique described in this paper provides a novel method to investigate the hemodynamics of complex cerebral vascular systems not accessible from previous clinical studies. (C) 2014 Elsevier Ltd. All rights reserved.