Association study of AMH and AMHRII polymorphisms with unexplained infertility
Association study of AMH and AMHRII polymorphisms with unexplained infertility
复制标题
DOI：
10.1016/j.fertnstert.2009.05.025
复制
发表时间：
2010-09-01
影响因子：
6.7
通讯作者：
Clementi, Maurizio
中科院分区：
文献类型：
--
作者：
Rigon, Chiara;Andrisani, Alessandra;Clementi, Maurizio
Objective: To investigate the association of AMH and AMHRII polymorphisms with reproductive abilities in a sample of women with idiopathic infertility.Design: Case-control study.Setting: University Department of Obstetrics and Gynecology, and University Unit of Clinical Genetics.Patient(s): 76 women with idiopathic sterility and 100 fertile women as controls.Intervention(s): Genotyping was performed by high-resolution melt analysis.Main Outcome Measure(s): Genotype distribution and allele frequency of AMH and AMHRII polymorphisms. Reconstruction of haplotype alleles to evaluate the linkage disequilibrium between single nucleotide polymorphisms.Result(s): Allele frequencies of -482 A>G, IVS 5-6 C>T, IVS 10+77 A>G, 146T>G polymorphisms are statistically significantly different in infertile patients compared with controls.Conclusion(s): Genetic variants of AMH and AMHRII genes seem to be associated with infertility, suggesting a role in the pathophysiology of normo-estrogenic and normo-ovulatory infertility. Aclearer understanding of their function in ovarian physiology may help clinicians to find a role for antimullerian hormone measurement in the field of reproductive medicine. (Fertil Steril (R) 2010;94:1244-8. (C) 2010 by American Society for Reproductive Medicine.)
