Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury
Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury
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DOI：
10.20738/johb.33.1_1
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发表时间：
2020-06
期刊：
影响因子：
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通讯作者：
Keita Kawarabayashi;F. Kano;Noboru Hashimoto;H. Hibi;Tsutomu Iwamoto;Akihito Yamamoto
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文献类型：
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作者：
Keita Kawarabayashi;F. Kano;Noboru Hashimoto;H. Hibi;Tsutomu Iwamoto;Akihito Yamamoto
放射引起的皮肤溃疡是癌症放射治疗的常见并发症。来自人类脱落乳牙（SHED）的干细胞可以再生各种组织。在这项研究中，我们研究了 SHED 条件培养基 (SHED-CM) 对辐射引起的溃疡的影响。用单剂量 15 Gy 的辐射对小鼠颈部进行局部照射。照射一周后，大部分野生型小鼠出现溃疡，周围出现严重红斑。静脉注射SHED-CM可有效抑制溃疡形成。组织学检查显示 SHED-CM 治疗抑制了辐射引起的真皮厚度和上皮增生。 SHED-CM 可能是治疗辐射引起的皮肤溃疡的有效选择。
Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.