Effects of candesartan on the renin system in conscious rats.
Effects of candesartan on the renin system in conscious rats.
复制标题
坎地沙坦对清醒大鼠肾素系统的影响。
DOI：
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发表时间：
1999
影响因子：
13.6
通讯作者：
A. Kurtz
中科院分区：
文献类型：
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作者：
C. Wagner;A. Kurtz
本研究旨在评估和比较卡地沙坦西列地酯对大鼠肾素系统的影响。雄性Sprague Dawley大鼠分别口服血管紧张素转换酶抑制剂雷米普利（7.5 mg/kg / d）、已建立的AngII-AT1受体阻阻剂氯沙坦（40 mg/kg / d）或坎地沙坦西列地酯（1 mg/kg / d） 3天，测定这些治疗对血浆肾素活性、肾素mRNA水平以及肾上腺血管i - at1a和血管i - at1b受体mRNA水平的影响。结果发现，所有药物导致血浆肾素活性和肾素mRNA水平的升高非常相似，肾上腺血管i - at1b受体mRNA水平的降低也非常相似。因此，坎地沙坦对体内肾素系统的影响与血管紧张素转换酶抑制剂或血管i - at1受体阻滞剂氯沙坦的影响没有什么不同。
This study aimed to assess and to compare the effects of cadesartan cilexetil on the renin system in rats. Male Sprague Dawley rats were orally treated either with the angiotensin-converting enzyme inhibitor ramipril (7.5 mg/kg per d), with the established AngII-AT1 receptor blocker losartan (40 mg/kg per d), or with candesartan cilexetil (1 mg/kg per d) for 3 d, and the effects of these treatments on plasma renin activity, renal renin mRNA levels, and adrenal levels of AngII-AT1a and AngII-AT1b receptor mRNA were determined. It was found that all drugs led to very similar increases in plasma renin activity and renin mRNA levels and to rather similar decreases in adrenal AngII-AT1b receptor mRNA levels. It is concluded therefore that the effects of candesartan on the renin system in vivo are not different from those obtained with angiotensin-converting enzyme inhibition or with the AngII-AT1 receptor blocker losartan.