A chimeric switch-receptor PD1-DAP10-41BB augments NK92-cell activation and killing for human lung Cancer H1299 Cell.
A chimeric switch-receptor PD1-DAP10-41BB augments NK92-cell activation and killing for human lung Cancer H1299 Cell.
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DOI：
10.1016/j.bbrc.2022.02.052
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发表时间：
2022-02
影响因子：
3.1
通讯作者：
Lingtong Zhi;Meichen Yin;Xin Su;Zikang Zhang;Hui Lu;Mingfeng Li;Changjiang Guo;Zhiyuan Niu
中科院分区：
文献类型：
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作者：
Lingtong Zhi;Meichen Yin;Xin Su;Zikang Zhang;Hui Lu;Mingfeng Li;Changjiang Guo;Zhiyuan Niu
设计了一种针对NK细胞的新型嵌合开关受体PD1-DAP10-41BB，修饰的NK92细胞通过触发细胞凋亡来介导对H1299细胞的清除，表达PD1-DAP10-41BB的NK92细胞在体内诱导对H1299细胞的肿瘤控制。
HighlightsA novel NK-tailored chimeric switch-receptor PD1-DAP10-41BB is rationally designed.Modified NK92 cells mediate the clearance of H1299 cells by triggering apoptosis.PD1-DAP10-41BB-expressing NK92 cells elicit in vivo tumor control of H1299 cells.