Serum uric acid and renal prognosis in patients with IgA nephropathy
Serum uric acid and renal prognosis in patients with IgA nephropathy
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DOI：
10.1159/000045939
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发表时间：
2001-04-01
期刊：
影响因子：
2.5
通讯作者：
Hikita, M
中科院分区：
文献类型：
--
作者：
Ohno, I;Hosoya, T;Hikita, M
背景/目的：本研究旨在阐明血清尿酸（SUA）的临床意义以及IgA肾病高尿酸血症与肾脏预后的关系。方法：对 748 名 IgA 肾病患者（432 名男性和 316 名女性）进行 SUA 与其他临床参数之间的相关性检查。在这些患者中，对226名（144名男性和82名女性）随访超过5年的患者进行了高尿酸血症与肾脏预后之间的关系检查。结果：在 IgA 肾病中，SUA 与肌酐清除率 (Ccr) 呈负相关，与尿蛋白和肾小管间质损伤呈正相关。高血压或弥漫性增生性肾小球肾炎患者的 SUA 较高。高尿酸血症是肾脏预后的危险因素，无论是血清肌酐（p = 0.0025）还是 Ccr（p = 0.0057）。在 56 例肾活检时 Ccr 正常的患者中，8 年后 13 例高尿酸血症患者的 Ccr 变化为 -22.3 +/- 20.8%，而 43 例无高尿酸血症患者的 Ccr 变化为 +2.6 +/- 39.4% (p = 0.0238)，高尿酸血症与 Ccr 恶化独立相关 (p = 0.0461)，结论：高尿酸血症患者的高尿酸血症与 Ccr 恶化独立相关。 IgA 肾病源自肾小球和肾小管间质损伤，并与高血压相关。高尿酸血症是 IgA 肾病肾脏预后的危险因素。版权所有 (C) 2001 S. Karger AG。巴塞尔。
Background/Aims: This study was designed to elucidate the clinical significance of serum uric acid (SUA) and the relationship between hyperuricemia and renal prognosis in IgA nepropathy. Methods: The correlation between SUA and other clinical parameters were examined in 748 IgA nephropathy patients (432 males and 316 females). Among these patients, 226 (144 males and 82 females) who were followed for more than 5 years were examined for the relationship between hyperuricemia and renal prognosis. Results: In IgA nephropathy, SUA correlated negatively with creatinine clearance (Ccr), and positively with urinary protein and tubulointerstitial damage. SUA was higher in patients with hypertension or diffuse proliferative glomerulonephritis. Hyperuricemia was a risk factor for renal prognosis, both in terms of serum creatinine (p = 0.0025) and Ccr (p = 0.0057). In 56 patients with normal Ccr at renal biopsy, the change of Ccr after more than 8 years was -22.3 +/- 20.8% in 13 patients with hyperuricemia, compared with +2.6 +/- 39.4% in 43 patients without hyperuricemia (p = 0.0238), Hyperuricemia was related independently to deterioration of Ccr (p = 0.0461), Conclusion: Hyperuricemia in IgA nephropathy is derived from both glomerular and tubulointerstitial damage, and correlated with hypertension. Hyperuricemia is a risk factor for renal prognosis in IgA nephropathy. Copyright (C) 2001 S. Karger AG. Basel.