Global visual scanning abnormalities in schizophrenia and bipolar disorder
Global visual scanning abnormalities in schizophrenia and bipolar disorder
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DOI：
10.1016/j.schres.2006.06.015
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发表时间：
2006-10-01
影响因子：
4.5
通讯作者：
St Clair, David
中科院分区：
文献类型：
--
作者：
Bestelmeyer, Patricia E. G.;Tatler, Benjamin W.;St Clair, David
面部图像的视觉扫描被广泛报道在精神分裂症中是异常的。这种受损的处理被认为是患者在社会交往中出现障碍的部分原因。本研究的目的是确定是否异常扫描是特定的社会内容的图像或扩展到其他类型的刺激。精神分裂症（n = 22），双相情感障碍（n = 19）和健康对照组（n = 3 - 7）的个人被要求查看一系列的28个图像或没有社会重要的内容（即面孔，风景，分形和噪声模式），而他们的眼球运动被记录视频眼动。比较了每个患者组和图像类型的扫描路径的时间和空间特征。独立的图像内容，精神分裂症患者表现出更少的固定，更长的固定时间，更长的扫视持续时间和峰值速度，和较小的扫视幅度相比，健康对照组。精神分裂症和双相情感障碍患者在任何时间变量上都没有显著差异。精神分裂症患者的注视位置分布与健康对照组的所有图片类型和双相情感障碍患者的所有，但面部图像显着不同。精神分裂症和双相情感障碍的异常扫描是独立的刺激类型，因此反映了全球视觉扫描障碍，而不是特定的面孔。空间扫描特征而非时间扫描特征可作为功能性精神病的生物标志物。(c)2006 Elsevier B. V.保留所有权利。
Visual scanning of face images is widely reported to be abnormal in schizophrenia. This impaired processing has been proposed to be partly responsible for patients' disturbance in social interactions. The present study was designed to determine whether abnormal scanning is specific to images with social content or extends to other types of stimuli. Individuals with schizophrenia (n = 22), bipolar disorder (n = 19) and healthy controls (n = 3 7) were asked to view a series of 28 images with or without socially important content (i.e. faces, landscapes, fractals and noise patterns) while their eye movements were recorded video-oculographically. Temporal and spatial characteristics of scan paths were compared for each patient group and picture type. Independent of image content, patients with schizophrenia exhibited fewer fixations, longer fixation duration, longer saccade duration and peak velocity, and smaller saccade amplitude compared with healthy controls. Patients with schizophrenia and bipolar disorder did not differ significantly from one another on any of the temporal variables recorded. Fixation location distributions of participants with schizophrenia differed significantly from that of healthy controls on all picture types and from patients with bipolar disorder on all but face images. Abnormal scanning in schizophrenia and also bipolar disorder was independent of stimulus type and therefore reflects a global visual scanning impairment not specific to faces. Spatial scanning characteristics but not temporal ones may serve as biomarkers in the functional psychoses. (c) 2006 Elsevier B.V. All rights reserved.