Physical activity frequency and risk of incident stroke in a national US study of blacks and whites.
Physical activity frequency and risk of incident stroke in a national US study of blacks and whites.
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DOI：
10.1161/strokeaha.113.001538
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发表时间：
2013-09
期刊：
影响因子：
8.3
通讯作者：
Howard VJ
中科院分区：
文献类型：
--
作者：
McDonnell MN;Hillier SL;Hooker SP;Le A;Judd SE;Howard VJ
定期进行身体活动是预防中风的重要建议。我们在中风地理和种族差异的原因 (REGARDS) 研究中比较了自我报告的体力活动 (PA) 与中风发生率的关联。 REGRARDS 招募了 30,239 名年龄≥45 岁的美国黑人 (42%) 和白人，每六个月对中风事件进行随访。排除既往中风的患者，分析涉及 27,348 名参与者，他们根据三类报告基线时中等强度 PA 的频率：无（缺乏身体活动）、每周 1-3 次和每周≥ 4 次。平均 5.7 年的随访期间发现了中风和 TIA 病例。构建 Cox 比例风险模型来检查自我报告的 PA 是否与中风风险相关。 33% 的参与者报告缺乏身体活动，其风险比 (HR) 为 1.20（[95% 置信区间 1.02–1.42]，p = 0.035）。对人口和社会经济因素的调整不会影响HR，但对传统卒中危险因素（糖尿病、高血压、体重指数、饮酒和吸烟）的进一步调整部分减弱了这种风险（HR 1.14 [0.95–1.37]，p = 0.17）。不同性别群体的 PA 频率与中风风险之间没有显着关联，尽管与每周报告 4 次或以上的男性相比，每周报告 PA 0-3 次的男性风险有增加的趋势。自我报告的低 PA 频率与中风风险增加相关。 PA 的任何影响都可能通过减少传统风险因素来调节。
Regular physical activity is an important recommendation for stroke prevention. We compared the associations of self-reported physical activity (PA) with incident stroke in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. REGARDS recruited 30,239 US blacks (42%) and whites, aged ≥45 with follow-up every six months for stroke events. Excluding those with prior stroke, analysis involved27,348participants who reported their frequency of moderate-vigorous intensity PA at baseline according to three categories: none (physical inactivity), 1–3 times/week and ≥ 4 times/week. Stroke and TIA cases were identified during an average of 5.7 years of follow-up. Cox proportional hazards models were constructed to examine whether self-reported PA was associated with risk of incident stroke. Physical inactivity was reported by 33% of participants and was associated with a hazard ratio (HR) of 1.20 ([95% confidence intervals 1.02–1.42], p = 0.035). Adjustment for demographic and socioeconomic factors did not affect HR, but further adjustment for traditional stroke risk factors (diabetes, hypertension, body mass index, alcohol use and smoking) partially attenuated this risk (HR 1.14 [0.95–1.37], p = 0.17). There was no significant association between PA frequency and risk of stroke by sex groups although there was a trend towards increased risk for men reporting PA 0–3 times a week compared to 4 or more times a week. Self-reported low PA frequency is associated with increased risk of incident stroke. Any effect of PA is likely to be mediated through reducing traditional risk factors.