Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury.
Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury.
复制标题
脊髓损伤后成年大鼠踝关节肌肉的神经肌肉传递失败和肌肉疲劳。
DOI：
10.1152/japplphysiol.00282.2009
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Burns,AnthonyS
中科院分区：
文献类型：
--
作者：
Ollivier-Lanvin,Karen;Lemay,MichelA;Tessler,Alan;Burns,AnthonyS
Current evidence suggests that significant morphological changes occur in nerve-muscle connections caudal to spinal cord injury (SCI). To determine whether neuromuscular junction (NMJ) function is compromised after SCI, we investigated the contribution of NMJ failure to hindlimb muscle fatigue in control and spinalized adult rats. Repetitive supramaximal nerve stimulation was applied to two muscle-nerve preparations: medial gastrocnemius (MG)-tibial and tibialis anterior (TA)-peroneal. NMJ transmission failure was evident in control and SCI animals after repetitive stimulation. At 2 wk post-SCI, NMJ transmission failure was greater in SCI animals compared with controls, but the difference was not significant (P= 0.205 for the MG andP= 0.053 for the TA). At 6 wk post-SCI, there was a significant but small difference in NMJ transmission failure for the TA between control and spinal animals. These results demonstrate that, although there may be a mild decrement in NMJ function, NMJ transmission remains largely intact for supramaximal nerve stimulation.
