Cancer-preventive effects of drinking green tea among a Japanese population
Cancer-preventive effects of drinking green tea among a Japanese population
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DOI：
10.1006/pmed.1997.0242
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发表时间：
1997-11-01
影响因子：
5.1
通讯作者：
Nakachi, K
中科院分区：
文献类型：
--
作者：
Imai, K;Suga, K;Nakachi, K
背景。实验室研究表明绿茶有预防癌症的作用，因此在人群中研究了饮用绿茶和癌症之间的关系。我们对日本人群进行了前瞻性队列研究，研究了绿茶消费与癌症发病率之间的关系。我们调查了居住在埼玉县一个小镇的8552名40岁以上的人的生活习惯，包括每天饮用绿茶的情况。在9年的随访研究中（71,248.5人年），我们在所有部位共发现384例癌症病例。我们发现喝绿茶和癌症发病率呈负相关，尤其是每天喝10杯以上的女性。在每天喝10杯以上的女性中，癌症发病率的增长速度随着年龄的增长而放缓，这与增加绿茶摄入量与癌症晚期发病有关的发现是一致的。饮用大量绿茶的女性的年龄标准化年平均发病率明显较低。在饮酒量最高的人群中，女性（RR = 0.57, 95% CI = 0.33-0.98）和男性（RR = 0.68, 95% CI = 0.39-1.21）患癌的相对风险（RR）也较低，尽管在男性中，即使按吸烟分层并校正酒精和饮食变量，其预防效果也没有达到统计学意义。我们的流行病学研究表明，绿茶对人类癌症有潜在的预防作用。(C) 1997学术出版社。
Background. Laboratory studies have revealed the cancer preventive effects of green tea, so the association between green tea consumption and cancer was examined in a human population.Methods. The association between green tea consumption and cancer incidence was studied in our prospective cohort study of a Japanese population. We surveyed 8,552 individuals over 40 years of age living in a town in Saitama prefecture on their living habits, including daily consumption of green tea. During the 9 years of follow-up study (71,248.5 person-years), we identified a total of 384 cases of cancer in all sites,Results. We found a negative association between green tea consumption and cancer incidence, especially among females drinking more than 10 cups a day, The slowdown in increase of cancer incidence with age observed among females who consumed more than 10 cups a day is consistent with the finding that increased consumption of green tea is associated with later onset of cancer. Age-standardized average annual incidence rate was significantly lower among females who consumed large amounts of green tea. Relative risk (RR) of cancer incidence was also lower among both females (RR = 0.57, 95% CI = 0.33-0.98) and males (RR = 0.68, 95% CI = 0.39-1.21) in groups with the highest consumption, although the preventive effects did not achieve statistical significance among males, even when stratified by smoking and adjusted for alcohol and dietary variables.Conclusion. Our epidemiological study showed that green tea has a potentially preventive effect against cancer among humans. (C) 1997 Academic Press.