Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
复制标题
DOI：
10.1073/pnas.0409336102
复制
发表时间：
2005-02-15
影响因子：
11.1
通讯作者：
Mirkin, CA
中科院分区：
文献类型：
--
作者：
Georganopoulou, DG;Chang, L;Mirkin, CA
最近开发的超灵敏生物条形码测定用于测量30个个体的脑脊液（CSF）中淀粉样蛋白β衍生的扩散配体（ADDL）的浓度，ADDL是一种潜在的可溶性致病性阿尔茨海默病（AD）标志物。诊断为AD的受试者的ADDL浓度始终高于年龄匹配的非痴呆对照组的CSF水平。由于其在CSF中的浓度低，因此不可能对CSF中的ADDL或任何其他潜在致病性AD标志物进行研究（
The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (