Experimental study of active control of microbubbles in blood flow by forming their aggregations
Experimental study of active control of microbubbles in blood flow by forming their aggregations
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通过形成聚集体主动控制血流中微泡的实验研究
DOI：
10.1109/ultsym.2011.0503
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
T. Chiba
中科院分区：
文献类型：
--
作者：
K. Masuda;R. Koda;N. Watarai;N. Shigehara;T. Ito;T. Kakimoto;Y. Miyamoto;S. Enosawa;T. Chiba
我们实验了一种用多个换能器发射超声平面波的人造血管来控制微气泡在流动中的行为的方法。由于初级Bjerknes力，微泡在流动中被推进，初级Bjerknes力是声波沿其传播方向推动障碍物沿着的物理现象。此外，当它们被放入超声场中时，由于次级Bjerknes力，它们形成聚集体，该次级Bjerknes力充当相邻微泡之间的吸引或排斥因素。因此，我们认为，形成气泡聚集体是有效的被推进之前，进入超声场，以接收更大的初级Bjerknes力。我们研究了气泡聚集现象，并观察了在各种超声暴露条件下人工血管中有和没有红细胞的聚集行为。结果，当形成微泡聚集体时，效率比不形成聚集体的条件提高更多。微泡附近红细胞的存在有助于推动血管壁的聚集体的大小增加。
We have experimented a method to control behavior of microbubbles in flow using an artificial blood vessel with multiple transducers to emit ultrasonic plane wave. Microbubbules are propelled in flow owing to a primary Bjerknes force, which is a physical phenomenon where an acoustic wave pushes an obstacle along its direction of propagation. Also they form aggregation when they are put into an ultrasound field because of secondary Bjerknes force, which acts as attractive or repulsive factor among neighboring microbubbles. Thus we consider that forming bubble aggregations is effective to be propelled before entering into an ultrasound field to receive greater primary Bjerknes force. We have investigated the phenomenon of bubble aggregations and observed behavior of aggregations with and without red blood cells in artificial blood vessels under various conditions of ultrasound exposure. As the results, when microbubble aggregations were formed, the efficiency was improved more than the condition without forming aggregation. The existence of red blood cells near microbubbles contributed to the increase in the size of aggregations propelled against the vessel wall.
影响因子：
2.9
作者：
Dayton, P;Klibanov, A;Ferrara, K
通讯作者：
Ferrara, K