The effect of sorghum resistance resistant starch-mediated equol on the histological morphology of the uterus and ovaries of postmenopausal rats
The effect of sorghum resistance resistant starch-mediated equol on the histological morphology of the uterus and ovaries of postmenopausal rats
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DOI：
10.1002/fsn3.1670
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发表时间：
2020-06-17
影响因子：
3.9
通讯作者：
Cao, Long-Kui
中科院分区：
文献类型：
--
作者：
Ge, Yun-Fei;Wei, Chun-Hong;Cao, Long-Kui
马酚是大豆苷元的代谢物，具有比大豆苷元更高的生物活性。Equol与雌激素受体联合使用，可以降低心血管疾病、骨质疏松症和乳腺癌等疾病的发生率，更有效地缓解围绝经期综合征的症状，并改善与年龄相关的子宫和卵巢的衰退。研究表明，食物成分会极大地影响肠道中马醇的形成。在肠道中，能够刺激发酵的非淀粉多糖含量很高，从而使肠道细菌能够快速完全地将大豆苷元转化为马酚。本研究以SD大鼠为模型，通过直接灌胃福尔斯坦建立绝经模型。在为期6周的实验中，豆浆灌胃给药降低了绝经后大鼠的体重，降低了大鼠的饲料利用率，增加了子宫、卵巢等器官的重量。血常规指标显示，RS灌胃未见不良反应。16S rDNA测序进一步证实了乳杆菌和梭状芽孢杆菌是将大豆苷元转化为木质素的细菌。
Equol is a metabolite of daidzein and has a higher biological activity than daidzein. Equol, combined with estrogen receptors, can reduce the incidence of diseases such as cardiovascular disease, osteoporosis, and breast cancer; more effectively alleviate the symptoms of perimenopausal syndrome; and improve age-related decline of the uterus and ovaries. Research has shown that food composition can greatly affect the formation of equol in the intestinal tract. In the intestines, the content of nonstarch polysaccharides that can stimulate fermentation is high, thereby allowing intestinal bacteria to quickly and completely transform the daidzein into equol. This study used Sprague Dawley (SD) rats as a model, where menopause was established through direct intragastric administration of formistan. In the 6-week-long experiment, intragastric administration of RS while feeding bean pulp reduced the body weight of postmenopausal rats, reduced the efficiency of feed utilization of rats, and increased the weight of organs such as the uterus and ovaries. Routine blood indexes showed that no adverse reactions were produced by intragastric administration of RS. 16s rDNA sequencing further verifiedLactobacillusandClostridiumXIVa, as the bacteria that converted daidzein into equol.