Urinary bladder, cystitis and nerve/urothelial interactions
Urinary bladder, cystitis and nerve/urothelial interactions
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DOI：
10.1016/j.autneu.2013.12.005
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Birder, Lori A.
中科院分区：
文献类型：
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作者：
Birder, Lori A.
功能性疼痛综合征的一个标志，例如膀胱疼痛综合征/间质性膀胱炎（BPS/IC），是在没有明显的感染或内脏或相关神经病变的情况下出现疼痛。这种综合征没有明确的定义，没有经过证实的病因，也没有能够消除症状的有效治疗方法。这种情况的特点是耻骨上疼痛，与膀胱充盈相关，还可能伴有持续强烈的排尿欲望、排尿频率增加和夜尿。这种疾病的严重病例主要影响女性，由于极度疼痛和尿频，通常难以治疗，会对患者的生活质量产生相当大的影响。此外，BPS/IC 患者还可能患有以疼痛为常见症状的合并症（如肠易激综合征、纤维肌痛）。解释膀胱疼痛综合征病理学的理论有很多，其中包括膀胱内壁的改变和细菌制剂的可能作用。 (C) 2013 Elsevier B.V. 保留所有权利。
A hallmark of functional pain syndromes, such as bladder pain syndrome/interstitial cystitis (BPS/IC) is pain in the absence of demonstrable infection or pathology of the viscera or associated nerves. There are no clear definitions of this syndrome, no proven etiologies and no effective treatments able to eradicate the symptoms. This condition is characterized by suprapubic pain, associated with bladder filling and can also be accompanied by a persistent strong desire to void, increased frequency of urination and nocturia. Severe cases of this disorder, which affects primarily women, can have considerable impact on the quality of life of patients due to extreme pain and urinary frequency, which are often difficult to treat. In addition, BPS/IC patients may also suffer co-morbid conditions where pain is a common symptom (such as irritable bowel syndrome, fibromyalgia). Theories explaining the pathology of bladder pain syndrome are many and include an altered bladder lining and possible contribution of a bacterial agent. (C) 2013 Elsevier B.V. All rights reserved.