Predictability modulates human brain response to reward
Predictability modulates human brain response to reward
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DOI：
10.1523/jneurosci.21-08-02793.2001
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发表时间：
2001-04-15
影响因子：
5.3
通讯作者：
Montague, PR
中科院分区：
文献类型：
--
作者：
Berns, GS;McClure, SM;Montague, PR
某些类别的刺激，如食物和药物，在激活奖赏区域方面非常有效。我们在人类身上表明，这些区域的活动可以通过两种轻微愉悦刺激--口服果汁和水--的顺序传递的可预测性来调节。使用功能磁共振成像，当刺激不可预测时，伏隔核和内侧眶前皮质对刺激的奖励活动最大。此外，受试者对果汁或水的偏好与奖励区域的活动并不直接相关，而是与感觉运动皮质的活动相关。对于愉悦的刺激，这些发现表明可预测性调节了人类奖励区域的反应，主观偏好可以从这种反应中分离出来。
Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects' stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.