Maternal thyroid function, prepregnancy obesity and gestational weight gainThe Generation R Study: A prospective cohort study
Maternal thyroid function, prepregnancy obesity and gestational weight gainThe Generation R Study: A prospective cohort study
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DOI：
10.1111/cen.13412
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发表时间：
2017-12-01
影响因子：
3.2
通讯作者：
Gaillard, Romy
中科院分区：
文献类型：
--
作者：
Collares, Fernanda M.;Korevaar, Tim I. M.;Gaillard, Romy
目的孕前肥胖和孕期体重增加过多与妊娠并发症有关。甲状腺功能与成年人身体质量指数(BMI)的差异有关。在一项以人群为基础的前瞻性队列研究中，我们测量了妊娠13.5周(95%范围：9.7-17.6周)的母亲TSH和FT4水平。结果TSH水平越高，孕前BMI越高[孕前TSH水平每SD升高0.18 kg/m(2)[95%CI：0.01，0.36]，孕周总体重增加0.02 kg/wk[95%CI：0.01，0.03]。孕妇FT4水平较高与较低的孕前BMI(孕妇FT4水平每SD升高的差值：-0.44 kg/m(2)[95%CI：-0.63，-0.26])和较低的妊娠总体重增加(差值：-0.01 kg/wk[95%CI：-0.02，-0.01]。孕妇甲状腺功能与妊娠早期体重增加的相关性强于妊娠中期和晚期体重增加。母亲甲状腺功能减退与孕前BMI和早孕体重增加有关，而母亲甲状腺功能亢进的影响则相反(P
ObjectiveMaternal prepregnancy obesity and excessive gestational weight gain are associated with pregnancy complications. Thyroid function is related to differences in body mass index (BMI) in adult populations. We examined the associations of maternal thyroid function in early pregnancy with maternal BMI and weight gain during pregnancy.Design and methodsIn a population-based prospective cohort study among 5726 mothers, we measured maternal TSH and FT4 levels at 13.5weeks of gestation (95% range: 9.7-17.6weeks). Maternal weight was assessed before pregnancy and in each trimester.ResultsHigher maternal TSH levels were associated with higher prepregnancy BMI (difference: 0.18kg/m(2) [95% CI: 0.01, 0.36] per SD increase in maternal TSH level) and higher total gestational weight gain (difference: 0.02kg/wk [95% CI: 0.01, 0.03] per SD increase in maternal TSH level). Higher maternal FT4 levels were associated with lower prepregnancy BMI (difference: -0.44kg/m(2) [95% CI: -0.63, -0.26] per SD increase in maternal FT4 level) and lower total gestational weight gain (difference: -0.01kg/wk [95% CI: -0.02, -0.01] per SD increase in maternal FT4 level). The associations of maternal thyroid function with weight gain in early pregnancy were stronger than those with weight gain in mid and late-pregnancy. Maternal hypothyroidism was associated with higher prepregnancy BMI and early pregnancy weight gain, whereas opposite effects were observed for maternal hyperthyroidism (P