Matrine-Type Alkaloids from the Seeds of Sophora alopecuroides and Their Potential Anti-inflammatory Activities
Matrine-Type Alkaloids from the Seeds of Sophora alopecuroides and Their Potential Anti-inflammatory Activities
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苦豆子种子中的苦参碱型生物碱及其潜在的抗炎活性
DOI：
10.1002/cbdv.202001066
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发表时间：
2021-03-03
影响因子：
2.9
通讯作者：
Li, Hong-Mei
中科院分区：
文献类型：
--
作者：
Li, Jian-Chun;Dai, Wei-Feng;Li, Hong-Mei
从苦豆子（SophoraalopecuroidesL.）种子中分得3个新的苦参碱型生物碱：8 β-羟基氧化槐定碱（1），9 β-羟基槐定碱（2），9 β-羟基异槐果碱（3），以及1个已知的类似物11，12-脱氢苦参碱（4）。新化合物的结构用广泛的光谱技术，包括实验和计算的ECD数据进行了鉴定。采用脂多糖刺激RAW264.7细胞产生NO的方法，评价了所有分离物的抗炎活性。其中，8 β-羟基氧基槐定碱（1）显示出显著的抑制作用，IC 50值为18.26 μ M。
Three new matrine-type alkaloids, 8 beta-hydroxyoxysophoridine (1), 9 beta-hydroxysophoridine (2), 9 beta-hydroxyisosophocarpine (3), together with one known analog, 11,12-dehydromatrine (4), were isolated from the seeds of Sophora alopecuroides L. The structures of new compounds were elucidated using extensive spectroscopic techniques including the experimental and calculated ECD data. The anti-inflammatory activities of all the isolates on NO production in RAW 264.7 cells stimulated by lipopolysaccharide were evaluated. Among them, 8 beta-hydroxyoxysophoridine (1) showed a significant inhibitory effect with an IC50 value of 18.26 mu M.