Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.
Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.
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DOI：
10.1016/j.jalz.2016.09.007
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Kawas CH
中科院分区：
文献类型：
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作者：
Corrada MM;Hayden KM;Paganini-Hill A;Bullain SS;DeMoss J;Aguirre C;Brookmeyer R;Kawas CH
我们调查了一个高龄队列中高血压发病年龄与痴呆风险之间的关系。参与者来自90+研究，这是一项基于人群的纵向研究，对象是来自休闲世界队列研究（LWCS）的90岁以上幸存者。我们使用20年前收集的90+研究和LWCS的自我报告信息估计高血压发病年龄。559名无痴呆症的参与者每6个月随访一次，长达10年。224名参与者在随访期间发生痴呆症（平均=2.8年）。与没有高血压的人相比，高血压发病年龄为80-89岁的参与者痴呆风险较低（HR=0.58，p=0.04），发病年龄为90岁以上的参与者风险最低（HR=0.37，p=0.004）。在老年发展高血压可以预防痴呆症。了解这种低风险的机制对于确定预防老年痴呆症的方法非常重要。
We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort. Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study (LWCS). We estimated hypertension onset age using self-reported information from The 90+ Study and LWCS, collected about 20 years earlier. 559 participants without dementia were followed every 6 months for up to 10 years. 224 participants developed dementia during follow-up (mean=2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80-89 years had a lower dementia risk (HR=0.58, p=0.04) and participants with an onset age of 90+ years had the lowest risk (HR=0.37, p=0.004). Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.