Liquid crystal elastomers as substrates for 3D, robust, implantable electronics
Liquid crystal elastomers as substrates for 3D, robust, implantable electronics
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液晶弹性体作为 3D、坚固、可植入电子产品的基材
DOI：
10.1039/d0tb00471e
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发表时间：
2020
影响因子：
7
通讯作者：
Ware, Taylor H.
中科院分区：
文献类型：
--
作者：
Maeng, Jimin;Rihani, Rashed T.;Javed, Mahjabeen;Rajput, Jai Singh;Kim, Hyun;Bouton, Ian G.;Criss, Tyler A.;Pancrazio, Joseph J.;Black, Bryan J.;Ware, Taylor H.
新的器件结构有利于与柔软和动态的生物组织的相互作用是留置生物传感器和神经接口的设计的关键。为了在体内长期使用此类器械，组件材料耐受生理上苛刻的机械和化学条件也至关重要。在这里，我们描述了机械和化学稳健的3D植入式电子器件的设计和制造。这是通过使用传统的光刻来在液晶弹性体（LCE）（一类形状可编程材料）上图案化电子器件来实现的。在模拟生理环境的体外加速条件下评价LCE的化学耐久性;例如，LCE在模拟体内>1年的水解介质下表现出小于1%的质量变化。通过采用扭曲的mixelces作为动态基板，我们展示了电子制造的平面基板上，但释放变形成编程的3D形状。这些形状被设计成使得固有的低失效应变材料能够是可拉伸的。例如，用于电极阵列的螺旋多通道电缆在浸泡在磷酸盐缓冲盐水中时，在60%应变下承受超过10000次循环的循环拉伸和屈曲。 我们设想这些基于LCE的电子器件可用于植入式神经接口和生物传感器中的应用。
New device architectures favorable for interaction with the soft and dynamic biological tissue are critical for the design of indwelling biosensors and neural interfaces. For the long-term use of such devices within the body, it is also critical that the component materials resist the physiological harsh mechanical and chemical conditions. Here, we describe the design and fabrication of mechanically and chemically robust 3D implantable electronics. This is achieved by using traditional photolithography to pattern electronics on liquid crystal elastomers (LCEs), a class of shape programmable materials. The chemical durability of LCE is evaluated under accelerated in vitro conditions simulating the physiological environment; for example, LCE exhibits less than 1% mass change under a hydrolytic medium simulating >1 year in vivo. By employing twisted nematic LCEs as dynamic substrates, we demonstrate electronics that are fabricated on planar substrates but upon release morph into programmed 3D shapes. These shapes are designed to enable intrinsically low failure strain materials to be extrinsically stretchable. For example, helical multichannel cables for electrode arrays withstand cyclic stretching and buckling over 10 000 cycles at 60% strain while being soaked in phosphate-buffered saline. We envision that these LCE-based electronics can be used for applications in implantable neural interfaces and biosensors.