Mortality of United Kingdom acrylonitrile polymerisation workers.
Mortality of United Kingdom acrylonitrile polymerisation workers.
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英国丙烯腈聚合工人的死亡率。
DOI：
10.1136/oem.38.3.247
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
J. T. Carter
中科院分区：
文献类型：
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作者：
J. B. Werner;J. T. Carter
本文调查了1950~1968年从事丙烯腈聚合和腈纶纺丝的1111名工人的死亡情况，直至1978年底。79人死亡。这些人来自英格兰、威尔士、苏格兰和北方爱尔兰的六家工厂，这些工厂在1968年之前就开始聚合。在暴露于丙烯腈至少一年的男性群体中，死亡总数低于预期。研究发现，所有癌症的死亡人数都有所增加，主要是肺癌、胃癌、结肠癌和脑癌，但这种增加在统计学上并不显著。在55 - 64岁的人群中，胃癌的发病率很高，在15 - 44岁的人群中，肺癌的发病率很高，对工厂死亡情况的分析表明，胃癌的发病率很高可能是区域因素造成的。考虑到肺癌发生在相对年轻的男性中这一事实，进一步研究了肺癌的过度，但发现三名年轻肺癌患者和匹配对照组暴露于丙烯腈的持续时间之间没有一致的差异，这项研究是有限的，需要在未来进一步分析。这些结果并不是结论性的，既不增加也不减少现有的怀疑，即丙烯腈是一种人类致癌物质，但与其他研究的证据一起，表明有必要继续监测英国的接触人群。
The mortality of 1111 men who worked on the polymerisation of acrylonitrile and the spinning of acrylic fibre from 1950 to 1968 was surveyed up to the end of 1978. Seventy-nine deaths were identified. The population was drawn from six factories, where polymerisation started before 1968, in England, Wales, Scotland, and Northern Ireland. In the group of men exposed to acrylonitrile for at least one year the total number of deaths was smaller than expected. An excess of deaths from all cancers was found, arising mainly from cancers of the lung, stomach, colon, and brain, but the excess was not statistically significant. Significant excesses of stomach cancer overall and in those aged 55-64, and of lung cancer in those aged 15-44 were found. Consideration of deaths according to factory indicated that the excesses of stomach cancer may have been due to regional factors. The excess of lung cancer was investigated further in view of the fact that, unusually, it occurred in relatively young men, but no consistent difference between the duration of exposure to acrylonitrile of the three young patients with lung cancer and matched controls was found. The study is limited and further analysis in the future is needed. The results are not conclusive and neither add to nor detract from existing suspicions that acrylonitrile is a human carcinogen but, taken together with evidence from other studies, indicate the necessity for the continuing surveillance of the exposed population in the United Kingdom.