Contemporary Issues in Exposure Assessment Using Biomonitoring.
Contemporary Issues in Exposure Assessment Using Biomonitoring.
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DOI：
10.1007/s40471-016-0075-7
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发表时间：
2016-06
影响因子：
3.3
通讯作者：
Calafat AM
中科院分区：
文献类型：
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作者：
Calafat AM
在环境流行病学中，过去几十年来，用于暴露评估的生物监测（即生物样本中环境化学品或其代谢物的痕量测量）的使用已大大增加。尽管暴露生物标志物应反映一个人在特定时间范围内接触目标化学物质（或其前体）的情况，但暴露的时间、持续时间和强度通常是未知的，并且在研究期间可能会有所不同。因此，评估超过单个时间点的暴露可能需要收集多个生物样本。值得注意的是，采集和样品处理程序将影响生物样本的完整性和有用性。所有上述因素都是正确解释生物监测数据的基础。我们将讨论暴露评估研究方案设计的相关性，以（a）确保生物监测样本反映预期暴露，（b）考虑目标生物标志物浓度的时间变异性，以及（c）促进研究之间生物监测结果的准确性和可比性评估。
In environmental epidemiology, use of biomonitoring (i.e., trace-level measurement of environmental chemicals or their metabolites in biospecimens) for exposure assessment has increased considerably in past decades. Although exposure biomarkers should reflect a person’s exposure to the target chemicals (or their precursors) within a specific timeframe, timing, duration, and intensity of exposures are normally unknown and likely vary within the study period. Therefore, evaluating exposure beyond a single time point may require collecting more than one biospecimen. Of note, collection and sample processing procedures will impact integrity and usefulness of biospecimens. All of the above factors are fundamental to properly interpret biomonitoring data. We will discuss the relevance of the exposure assessment study protocol design to (a) ensure that biomonitoring specimens reflect the intended exposure, (b) consider the temporal variability of concentrations of the target biomarkers, and (c) facilitate the evaluation of accuracy and comparability of biomonitoring results among studies.