Development of the polymer micelle carrier system for doxorubicin
Development of the polymer micelle carrier system for doxorubicin
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DOI：
10.1016/s0168-3659(01)00341-8
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发表时间：
2001-07-06
影响因子：
10.8
通讯作者：
Kataoka, K
中科院分区：
文献类型：
--
作者：
Nakanishi, T;Fukushima, S;Kataoka, K
我们展示了多柔比星（DOX）的聚合物胶束载体系统NK 911的临床前研究结果。NK 911胶束载体由聚乙二醇和多柔比星-聚天冬氨酸结合物组成。它具有高疏水性内核，因此可以捕获足够量的DOX。NK 911具有直径约40 nm的小粒径，其通过EPR效应在肿瘤组织中积累，显示出比游离DOX强得多的活性。我们计划从2001年起在日本国立癌症中心医院进行临床试验。(C)2001年，爱思唯尔科学。All rights reserved.
We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated doxorubicin-polyaspartic acid. It has high hydrophobic inner core, and therefore can entrap the sufficient amount of DOX. NK911 has a small particle size of about 40 nm in diameter that accumulates in tumor tissue by EPR effect showing much stronger activity than the free DOX. We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001. (C) 2001 Elsevier Science BY. All rights reserved.