Uptake of the neurotransmitter candidate glutamate by glia
Uptake of the neurotransmitter candidate glutamate by glia
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神经胶质细胞对候选神经递质谷氨酸的摄取
作者：
F. Henn;M. Goldstein;A. Hamberger
谷氨酸是哺乳动物突触的兴奋性递质的主要候选者，在哺乳动物的初级传入通路和皮质通路中起中介作用。为了获得证据，各种实验室都在寻找一种机制，可以有效地将谷氨酸从突触裂隙中移除。按照单胺类突触的模式，即高亲和力摄取系统明显定位于突触前膜，在作用于突触后膜后移除递质2，人们一直在寻找用于去除谷氨酸的高亲和力摄取系统。Logan和Snyder3描述了突触体内谷氨酸的高亲和力运输系统，并假设它可能用于定位谷氨酸介导的突触。最近的证据表明，参与从突触间隙移除假定的氨基酸递质的运输系统并不局限于突触。
GLUTAMIC acid is the primary candidate for a role as an excitatory transmitter at synapses mediating the primary afferent pathway and cortical pathways in mammals1. Seeking to gain evidence for this, various laboratories have looked for a mechanism for the eflficient removal of glutamic acid from the synaptic cleft. Following the paradigm of monoamine synapses, in which high affinity uptake systems apparently localised in the presynaptic membrane remove transmitter after its action at the postsynaptic membrane2, high affinity uptake systems for glutamate removal have been sought. Logan and Snyder3 described a high affinity transport system for glutamate in a synaptosomal preparation, and postulated that it might serve to localise glutamate-mediated synapses. Recent evidence has suggested that the transport systems involved in the removal of putative amino acid transmitters from the synaptic cleft are not localised exclusively in the synapse.