Association between Campylobacter infection and Guillain-Barre syndrome
Association between Campylobacter infection and Guillain-Barre syndrome
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DOI：
10.1086/513783
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发表时间：
1997-12-01
影响因子：
6.4
通讯作者：
Allos, BM
中科院分区：
文献类型：
--
作者：
Allos, BM
格林-巴利综合征（GBS）是一种引起上行性麻痹的神经系统疾病，影响着世界各地的人们。急性感染性疾病先于50%-75%的GBS病例。虽然许多传染性病原体与GBS有关，但最强的记录关联是弯曲杆菌感染。支持弯曲杆菌感染是GBS触发因素的第一条证据是轶事报告。第二个证据是血清学调查，这表明GBS患者的血清含有抗空肠弯曲菌抗体，与近期感染一致。最后，培养研究已经证明，高比例的GBS患者有C。在神经系统症状发作时粪便中有空肠。当GBS之前有C时，神经症状更严重，更可能是不可逆的。空肠感染每1058例弯曲杆菌感染中有1例导致GBS，158例弯曲杆菌0：19型感染中有1例导致GBS。
Guillain-Barre syndrome (GBS), a neurologic disease that produces ascending paralysis, affects people all over the world. Acute infectious illnesses precede 50%-75% of the GBS cases. Although many infectious agents have been associated with GBS, the strongest documented association is with Campylobacter infection. The first line of evidence supporting Campylobacter infection as a trigger of GBS is anecdotal reports. The second line of evidence is serologic surveys, which have demonstrated that sera from GBS patients contain anti-Campylobacter jejuni antibodies, consistent with recent infection. Finally, culture studies have proven that a high proportion of GBS patients have C. jejuni in their stools at the time of onset of neurologic symptoms. Neurologic symptoms are more severe and more likely to be irreversible when GBS is preceded by C. jejuni infection. One of every 1058 Campylobacter infections results in GBS, and 1 of 158 Campylobacter type 0:19 infections results in GBS.