A Randomized Trial of Deferred Stenting Versus Immediate Stenting to Prevent No- or Slow-Reflow in Acute ST-Segment Elevation Myocardial Infarction (DEFER-STEMI)
A Randomized Trial of Deferred Stenting Versus Immediate Stenting to Prevent No- or Slow-Reflow in Acute ST-Segment Elevation Myocardial Infarction (DEFER-STEMI)
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DOI：
10.1016/j.jacc.2014.02.530
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发表时间：
2014-05-27
影响因子：
24
通讯作者：
Berry, Colin
中科院分区：
文献类型：
--
作者：
Carrick, David;Oldroyd, Keith G.;Berry, Colin
目的 本研究的目的是评估在初次经皮冠状动脉介入治疗 (PCI) 治疗 ST 段抬高型心肌梗死 (STEMI) 时，延迟支架置入是否可以减少无复流并挽救心肌。 背景 无复流与 STEMI 的不良结局相关。 方法 这是一项前瞻性、单中心、随机、对照、概念验证试验，对象为无复流危险因素≥1 的再灌注 STEMI 患者。随机分组为延迟支架置入术和 4 至 16 小时后意向支架置入术，或常规治疗和立即支架置入术。主要结局是无/慢复流的发生率（心肌梗死中的溶栓
Objectives The aim of this study was to assess whether deferred stenting might reduce no-reflow and salvage myocardium in primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI).Background No-reflow is associated with adverse outcomes in STEMI.Methods This was a prospective, single-center, randomized, controlled, proof-of-concept trial in reperfused STEMI patients with >= 1 risk factors for no-reflow. Randomization was to deferred stenting with an intention-to-stent 4 to 16 h later or conventional treatment with immediate stenting. The primary outcome was the incidence of no-/slow-reflow (Thrombolysis In Myocardial Infarction