Occupational exposures and risk of systemic lupus erythematosus: a review of the evidence and exposure assessment methods in population- and clinic-based studies
Occupational exposures and risk of systemic lupus erythematosus: a review of the evidence and exposure assessment methods in population- and clinic-based studies
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DOI：
10.1177/0961203306069346
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Cooper, G. S.
中科院分区：
文献类型：
--
作者：
Parks, C. G.;Cooper, G. S.
流行病学和实验研究表明，职业暴露在系统性红斑狼疮（SLE）的发展中具有潜在的作用。在职业性二氧化硅暴露和SLE的研究中已经确定了一种合理的关联，并通过在狼疮易感小鼠中探索与细胞凋亡和免疫失调相关的潜在机制的实验研究进行了补充。溶剂三氯乙烯在狼疮易感小鼠中的实验研究提供了对免疫功能影响的证据，包括增加自身抗体的产生和CD 4 + T细胞的活化。然而，很少有关于职业性溶剂暴露和SLE的研究，而且现有的研究几乎没有证据表明两者之间存在关联。现有研究表明农药对SLE的潜在影响，但与溶剂一样，可能涉及的具体农药类型尚不清楚。我们对职业暴露在SLE中的作用的理解可以通过使用类似的问卷调查和暴露评估方法进行更大规模、多中心或平行研究来提高。需要使用可比暴露措施进行多项研究，以提供足够的样本量来检查基因-环境相互作用。我们提供了一个总体概述的数据要求和方法，可用于评估和评价职业暴露的临床和人群为基础的研究SLE。
Epidemiologic and experimental research suggests a potential role of occupational exposures in the development of systemic lupus erythematosus (SLE). A plausible association has been identified in studies of occupational silica exposure and SLE, complemented by experimental studies in lupus-prone mice exploring potential mechanisms related to apoptosis and immune dysregulation. Experimental studies of the solvent trichloroethylene in lupus-prone mice provide evidence of effects on immune function, including increased production of autoantibodies and activation of CD4+ T cells. However, few studies of occupational solvent exposure and SLE have been conducted, and those that are available show little evidence of an association. There is some suggestion from the available studies of the potential influence of pesticides on SLE, but as with solvents, the specific type of pesticides that may be implicated is not known. Our understanding of the role of occupational exposures in SLE could be advanced by the development of larger, multisite or parallel studies that utilize similar questionnaire and exposure evaluation methods. Multiple studies using comparable exposure measures are needed to provide sufficient sample size for examining gene-environment interactions. We provide a general overview of data requirements and methods available for the assessment and evaluation of occupational exposures in clinical and population-based studies of SLE.