Tumor necrosis factor-alpha and transforming growth factor-beta1 in chronic periapical lesions
Tumor necrosis factor-alpha and transforming growth factor-beta1 in chronic periapical lesions
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DOI：
10.1067/moe.2000.108958
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发表时间：
2000-10-01
期刊：
影响因子：
--
通讯作者：
Andersson, L
中科院分区：
文献类型：
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作者：
Danin, J;Linder, LE;Andersson, L
Objective.促炎细胞因子参与根尖周病变的发病机制。本研究的目的是评估肿瘤坏死因子-α细胞因子的存在，（TNF-α）和转化生长因子-β（1）研究设计：25例患者中，每例患者一颗牙齿被根端切除，收集根尖周病变，结果25个皮损中有21个检测到TGF-β（1），而在瘢痕组织中未检测到TGF-β（1）活性。每毫克组织中的TGF-β（1）与病变直径之间存在统计学显著相关性。仅在2例标本中检测到TNF-α。TGF-β 1在根尖周肉芽肿和囊肿中表达，但在瘢痕组织中不表达。每毫克组织中TGF-β 1的含量与病变的大小之间存在显著的相关性。
Objective. Proinflammatory cytokines are involved in the pathogenesis of periapical lesions. The purpose of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(1) (TGF-beta(1)) in periapical pathosis and to determine their relationship to the size of the lesions.Study design, One tooth from each of 25 patients was root-end resected, and the periapical lesion was collected, The amounts of TNF-alpha and TCF-beta(1) were assessed by enzyme-linked immunosorbent assay.Results, TGF-beta(1) was detected in 21 of 25 lesions; In samples with scar tissue, no TGF-beta(1) activity was detected. A statistically significant correlation was found between TGF-beta(1) per milligram of tissue and the diameter of the lesions. TNF-alpha was detected in only 2 samples.Conclusions. TGF-beta(1) was present in periapical granulomas and cysts but not in lesions with scar tissue. The correlation between the amount of TGF-beta(1) per milligram of tissue and the size of the lesion was significant.