Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: effects of estrogen replacement therapy.
Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: effects of estrogen replacement therapy.
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健康老年女性的尿游离皮质醇和基线和压力条件下的睡眠：雌激素替代疗法的影响。
DOI：
10.1046/j.1365-2869.2001.00236.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Scanlan,J
中科院分区：
文献类型：
--
作者：
Prinz,P;Bailey,S;Moe,K;Wilkinson,C;Scanlan,J
本研究的目的是检查 24 小时轻度压力（留置静脉导管）对绝经后女性皮质醇和睡眠的影响，并评估雌激素替代治疗 (ERT) 状态造成的差异。这项研究在华盛顿大学医学中心的综合临床研究中心进行，检查了基线和压力条件下的睡眠、皮质醇和睡眠-皮质醇关系，并将接受 ERT 的女性与未接受 ERT 的女性进行了比较。 42 名女性（年龄 = 69.6±6.2 岁 [SD]）参与其中，其中 20 人正在接受 ERT。在 24 基线和压力条件下测量尿游离皮质醇 (UFC) 水平和睡眠多导睡眠图。两组人的睡眠在压力条件下均受到损害；与基线条件相比，压力条件下的平均 UFC 水平更高，睡眠效率和第 2、3 和 4 阶段睡眠时间减少，早晨起床时间更早。对于合并组，24 小时 UFC 和睡眠之间的年龄控制相关性在两种情况下均显着：在基线时，UFC 水平与较早起床时间和较少的 REM 睡眠相关，而在睡眠效率降低的压力下，第 2、3、4 阶段睡眠时间减少，REM 睡眠减少，起床时间较早。当血浆雌激素受到统计控制时，UFC 与睡眠/睡眠时间之间的负显着相关模式仍然存在。然而，当单独检查各组时，显着的负 UFC-睡眠关系仅限于非 ERT 组。对于未接受 ERT 的老年女性来说，24 小时 UFC 升高与睡眠受损和早醒有关，但对于接受 ERT 的女性则不然。
The purpose of this study was to examine the effects of a mild 24‐h stress (indwelling IV catheter) on cortisol and sleep in postmenopausal women, and to evaluate differences due to estrogen replacement therapy (ERT) status. This study, conducted in the General Clinical Research Center at the University of Washington Medical Center, examined sleep, cortisol and sleep‐cortisol relationships in both baseline and stress conditions, and compared women on ERT with women not on ERT. Forty‐two women (age=69.6 ± 6.2 years [SD]), of whom 20 were on ERT, participated. Urinary free cortisol (UFC) levels and sleep polysomnography were measured over both 24‐baseline and stress condition. Sleep was impaired in the stress condition for both groups; mean UFC levels were higher, sleep efficiency and minutes of stages 2, 3 and 4 sleep were reduced, and morning risetime was earlier in the stress than baseline condition. For the combined groups, age‐controlled correlations between 24‐h UFC and sleep were significant in both conditions: at baseline, UFC levels were associated with earlier time of rising and less REM sleep, and under stress with reduced sleep efficiency, there was reduced minutes of stages 2, 3, 4 sleep, reduced REM sleep, and an earlier risetime. The pattern of negative significant correlations between UFC and sleep/sleep timing remained when plasma estrogen was statistically controlled; however, when groups were examined separately, the significant negative UFC‐sleep relationships were confined to the non ERT group. Elevated 24‐h UFC is associated with impaired sleep and earlier awakening in older women not on ERT, but not in women on ERT.