Estrogen replacement attenuates effects of scopolamine and lorazepam on memory acquisition and retention
Estrogen replacement attenuates effects of scopolamine and lorazepam on memory acquisition and retention
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DOI：
10.1006/hbeh.1998.1452
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发表时间：
1998-10-01
影响因子：
3.5
通讯作者：
Johnson, DA
中科院分区：
文献类型：
--
作者：
Gibbs, RB;Burke, AM;Johnson, DA
一个多试验被动回避范例被用来检查和比较雌激素替代减弱毒蕈碱拮抗剂东莨菪碱和苯二氮卓劳拉西泮产生的学习和记忆缺陷的能力。为了区分对习得的影响和对保持的影响，使用了多项试验范式。雌激素替代显着衰减东莨菪碱诱导的赤字被动回避收购，但不保留。只有当分析仅限于血清雌二醇水平的动物时，才观察到雌激素减弱东莨菪碱对获得的影响的能力
A multiple-trial passive avoidance paradigm was used to examine and compare the ability for estrogen replacement to attenuate learning and memory deficits produced by the muscarinic antagonist scopolamine and the benzodiazepine lorazepam. The multiple-trial paradigm was used in order to distinguish effects on acquisition from effects on retention. Estrogen replacement significantly attenuated a scopolamine-induced deficit on passive avoidance acquisition, but not retention. The ability for estrogen to attenuate the effect of scopolamine on acquisition was observed only when the analysis was limited to animals with serum levels of estradiol