INCREASED ERROR-RELATED BRAIN ACTIVITY IN YOUTH WITH OBSESSIVE-COMPULSIVE DISORDER AND UNAFFECTED SIBLINGS
INCREASED ERROR-RELATED BRAIN ACTIVITY IN YOUTH WITH OBSESSIVE-COMPULSIVE DISORDER AND UNAFFECTED SIBLINGS
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DOI：
10.1002/da.22035
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发表时间：
2013-01-01
影响因子：
7.4
通讯作者：
Hanna, Gregory L.
中科院分区：
文献类型：
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作者：
Carrasco, Melisa;Harbin, Shannon M.;Hanna, Gregory L.
背景 强迫症（OCD）的病理生理学涉及连接前扣带皮层（ACC）与其他大脑区域的皮质纹状体回路的活动增加。错误相关负性 (ERN) 是错误响应后事件相关电位的负偏转，被认为反映了 ACC 活动。这项研究的目的是通过比较儿科强迫症患者、儿科强迫症患者未受影响的兄弟姐妹和健康对照的 ERN 振幅，评估 ERN 作为强迫症生物标志物的作用。方法 在 Eriksen 侧翼任务中测量 ERN 和正确反应负性 (CRN)，以评估 40 名终生诊断为强迫症的青少年、19 名未受影响的强迫症患者兄弟姐妹以及 40 名年龄在 10 至 17 岁之间的无关健康对照受试者的表现监测。通过广义估计方程方法使用线性回归来比较组间的 ERN 和 CRN 幅度，以解释相关数据。结果与健康对照相比，儿童强迫症患者和未受影响的兄弟姐妹的 ERN 振幅均显着增加。 CRN 振幅没有显着的组间差异。患者的 ERN 幅度与 OCD 症状严重程度、当前诊断状态或治疗效果无关。结论 不仅在儿童强迫症患者中，而且在未受影响的兄弟姐妹中也观察到与错误相关的脑电位增加。结果提供证据表明，与错误相关的大脑活动增强可能作为青少年强迫症的生物标志物，与临床症状的存在无关。 ERN 可能是强迫症遗传研究中有用的定量表型。抑郁与焦虑 30: 39-46, 2013。(C) 2012 Wiley periodicals, Inc.
Background The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential following an erroneous response and is thought to reflect ACC activity. This study was done to assess the ERN as a biomarker for OCD by comparing ERN amplitudes in pediatric OCD patients, unaffected siblings of pediatric OCD patients, and healthy controls. Methods The ERN and correct response negativity (CRN) were measured during an Eriksen flanker task to assess performance monitoring in 40 youth with a lifetime diagnosis of OCD, 19 unaffected siblings of OCD patients, and 40 unrelated healthy comparison subjects ranging in age from 10 to 17 years. ERN and CRN amplitudes were compared between groups using linear regression by the generalized estimating equation method to account for correlated data. Results Compared to healthy controls, ERN amplitude was significantly increased in both pediatric OCD patients and unaffected siblings. There were no significant group differences in CRN amplitude. ERN amplitude in patients was unrelated to OCD symptom severity, current diagnostic status, or treatment effects. Conclusions Increased error-related brain potentials were observed not only in pediatric OCD patients but also in unaffected siblings. The results provide evidence that enhanced error-related brain activity may serve as a biomarker for OCD in youth that is independent of the presence of clinical symptoms. The ERN may be a useful quantitative phenotype in genetic studies of OCD. Depression and Anxiety 30: 39-46, 2013. (C) 2012 Wiley Periodicals, Inc.