Bacterial outer membrane vesicles as a platform for biomedical applications: An update
Bacterial outer membrane vesicles as a platform for biomedical applications: An update
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细菌外膜囊泡作为生物医学应用的平台：更新
DOI：
10.1016/j.jconrel.2020.04.031
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发表时间：
2020-07-10
影响因子：
10.8
通讯作者：
Wang, Yucai
中科院分区：
文献类型：
--
作者：
Li, Min;Zhou, Han;Wang, Yucai
外膜囊泡(OMV)是由革兰氏阴性杆菌在体外和体内产生的。OMVS是由脂质双层膜形成的纳米球形载体，含有多种亲本细菌衍生成分。基于细菌抗原、病原体相关分子模式(PAMPs)、粘附素、各种蛋白质和囊泡结构的存在，OMV已被开发为生物医学应用，如细菌疫苗、佐剂、癌症免疫治疗药物、药物输送载体和抗细菌粘附剂。本文分析了OMV的结构和组成对其应用的贡献，总结了用于分离和表征OMV的方法，并重点介绍了OMV在生物医学应用中的最新进展和未来前景。
Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria bothin vitroandin vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and contain multiple parent bacteria-derived components. Based on the presence of bacterial antigens, pathogen-associated molecular patterns (PAMPs), adhesins, various proteins and the vesicle structure, OMVs have been developed for biomedical applications as bacterial vaccines, adjuvants, cancer immunotherapy agents, drug delivery vehicles, and anti-bacteria adhesion agents. In this review, we analyze the contributions of the structure and composition of OMVs to their applications, summarize the methods used to isolate and characterize OMVs, and highlight recent progress and future perspectives of OMVs in biomedical applications.