Midarm muscle circumference, physical performance and mortality: Results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)
Midarm muscle circumference, physical performance and mortality: Results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)
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DOI：
10.1016/j.clnu.2009.12.006
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发表时间：
2010-08-01
影响因子：
6.3
通讯作者：
Onder, Graziano
中科院分区：
文献类型：
--
作者：
Landi, Francesco;Russo, Andrea;Onder, Graziano
背景与目的：肌肉减少症是老年人身体虚弱和预后不良的可靠标志。我们评估了上臂肌围（MAMC）和体能，肌肉力量，功能状态和生存的80岁或以上的人之间的关系。方法：数据是从基线评估的老龄化和长寿研究在Sirente地理区域（ilSIRENTE研究）（n = 357）。计算MAMC时考虑了上臂中围和右臂三头肌皮褶厚度。使用基于3项定时测试（4米步行速度测试、平衡测试和椅子站立测试）的身体表现成套评分评估身体表现。协方差分析，以评估不同的MAMC水平和身体功能之间的关系。采用考克斯比例回归模型估计MAMC水平下死亡的粗风险比和校正风险比以及95%置信区间。在调整了潜在的混杂因素（包括年龄、性别、独居、感觉障碍）后，（听力和视力）、体重指数、白蛋白和胆固醇-身体表现和功能（其使用4米步行速度测试、短身体性能成套测验评分、手握力测量）随着MAMC增加而显著改善。与低MAMC三分位数的受试者相比，高MAMC三分位数的受试者死亡风险较低（校正风险比（HR）0.45; 95%置信区间（CI）0.23-0.87）。结论：本研究表明，在社区居住的老年受试者中，肌肉质量可能与功能表现和生存呈正相关。(C)2009 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. We evaluated the relationship between midarm muscle circumference (MAMC) and physical performance, muscle strength, functional status and survival in persons aged 80 years or older.Methods: Data are from the baseline evaluation of the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study) (n = 357). MAMC was calculated taking into account the mid upper arm circumference and the triceps skinfold thickness of the right arm. Physical performance was assessed using the physical performance battery score, which is based on three timed tests: 4-m walking speed test, the balance test and the chair stand test. Analyses of covariance were performed to evaluate the relationship between different MAMC levels and physical function. Cox proportional regression models were used to estimate crude and adjusted hazard ratios and 95% confidence intervals of death by MAMC levels.Results: After adjustment for potential confounders - which included age, gender, living alone, sensory impairments (hearing and vision), body mass index, albumin and cholesterol - physical performance and function (which were measured using the 4-m walking speed test, the Short Physical Performance Battery score, the hand grip strength), improved significantly as MAMC increased. Compared with those in the low MAMC tertile, subjects in the high MAMC tertile had a lower risk of death (adjusted hazard ratio (HR) 0.45; 95% Confidence Interval (CI) 0.23-0.87).Conclusions: The present study suggests that among community-dwelling old-old subjects muscle mass may be positively related to functional performance and survival. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.